Clinical data of the studied individuals
| Sample type | Samples (n) | Age (mean±SD) | BMI (mean±SD) | Males | Tumour size (mean±SD) | Rectal bleeding (%) | Alcohol (1st quantile, third quantile) (units/week) | Currently smoking (%) |
| Tissue controls | 59 | 53.2±13.5 | 27.4±6.1 | 44.1 | NA | 57.7 | 1 (1, 10) | 4 |
| Off CRC | 74 | 66±11.3 | 28.7±5.7 | 66.7 | 3.2±1.8 | 65.6 | 2 (1, 10) | 10.4 |
| Off Polyps | 31 | 61.6±14.8 | 28.8±5 | 71 | NA | 38.7 | 1 (1, 10) | 13.3 |
| On CRC | 65 | 67±11.6 | 28.8±5.8 | 60.9 | 3.6±2 | 64.4 | 2 (0.8, 10) | 5 |
| On Polyps | 2 | 76.5±0.7 | 27.4±0.9 | 100 | NA | 50 | 7.5 (4.2, 10.8) | 0 |
| Stool controls | 62 | 63.9±11.1 | 28.2±5.4 | 50.9 | NA | 55.6 | 1 (0.2, 6.2) | 0 |
| Stool CRC | 69 | 65.3±10.8 | 28.4±6.1 | 66.7 | 3.1±1.7 | 65.5 | 2 (1, 11.2) | 11.3 |
| Stool polyp | 23 | 60.4±13.4 | 29.3±5.4 | 78.3 | NA | 39.1 | 4 (1, 13.5) | 17.4 |
| Swab controls | 25 | 51.5±12.4 | 27.1±5.5 | 37.5 | NA | 57.9 | 1 (1, 6) | 0 |
| Swab CRC | 45 | 65.7±10.9 | 27.1±5 | 56.1 | 3.3±1.9 | 66.7 | 2 (1, 9) | 0 |
| Swab polyp | 21 | 59.2±15.1 | 28.5±5.2 | 71.4 | NA | 38.1 | 1 (1, 10) | 10 |
BMI, body mass index; CRC, colorectal cancer.