Symptoms assessed across PROs in CD
| Symptom | CDSD112 | CD-PRO27 | CSI31 | CDAQ121 | GSRS117 | CD-GSRS148 |
| Abdominal pain | X | X | X | X | X | X |
| Diarrhoea | X | X | X | X† | X | X |
| Bloating | X | X | X | X | X | X |
| Nausea | X | X | X | X | X | X |
| Constipation | X | X† | X | |||
| Fatigue* | X | X | X | X | ||
| Headache* | X | X | X | |||
| Skin rash | X | |||||
| Flatulence | X | X | X | X | ||
| Burping | X | X | ||||
| Problems thinking* | X | X | ||||
| Incomplete emptying | X | X | ||||
| Loss of appetite | X | |||||
| Hunger pains | X | X | X | |||
| Stomach rumbling | X | X | X | X | ||
| Reflux | X |
*Removed from final PRO as per the Food and Drug Administration recommendations.
†Assessed in a single domain.
CD, coeliac disease; CDAQ, Celiac Disease Assessment Questionnaire; CDSD, Celiac Disease Symptom Diary; CSI, Celiac Symptom Index; GSRS, Gastrointestinal Symptom Rating Scale; PRO, patient-reported outcome.