Table 1

Faecal bile acid levels

Mdr2−/− control (pmol/mg) Mdr2−/− colesevelam (pmol/mg)
αMCA21.4+/-11.6399.8+/-34.2*
βMCA125.3+/-39.8450+/-82.2*
οMCA334.4+/-192.3300.1+/-59.1
CA47.7+/-32.21141.9+/-371.9*
CDCA4.6+/-3.6238.5+/-65.1*
DCA142.7+/-63.33072.7+/-914.8*
UDCA2.2+/-1.119.1+/-3.8*
LCA15.1+/-5.9265.8+/-107.0*
TαMCA2.2+/-1.242.0+/-40.9*
TβMCA58.4+/-23.279.3+/-40.9
TωMCA10.0+/-4.53.5+/-1.6*
TCA51.4+/-15.9226.2+/-153.2
TCDCA4.2+/-3.7135.2+/-76.2*
TDCA0.8+/-0.849.4+/-40.9*
TUDCA0.8+/-0.63.3+/-1.7*
TLCAnd3.5+/-2.2*
Total BAs839.9+/-280.36475.6+/-1202.6*
  • *Significant difference from Mdr2−/− control; p<0.05.

  • BA, bile acid; CA, cholic acid; DCA, deoxycholic acid; MCA, mucholic acid; nd, not detectable; TCA, taurine-conjugated cholic acid; TCDCA, taurine-conjugated deoxycholic acid; TDCA, taurine-conjugated; deoxycholic acid; TCDCA, taurine-conjugated chenodeoxycholic acid; TLCA , taurine-conjugated lithocholic acid; TαMCA, tauro-alpha-muricholic acid; TβMCA, tauro-beta-muricholic acid; TωMCA, tauro-omega-muricholic acid; TUDCA, taurine-conjugated ursodeoxycholic acid.