Bile acid-related gene expression in non-alcoholic steatohepatitis (NASH) livers (microarray)*
| Function | Gene ID | GenBank ID | Control (n=5) | NASH (n=12) | NASH/Control | p Value |
| Bile acid synthesis | ||||||
| 7a-hydroxylase | CYP7A1 | NM_000780.2 | 0.47±0.14† | 4.34±0.62 | 9.30 | 0.001 |
| Sterol 27-hydroxylase | CYP27A1 | NM_000784.2 | 73.76±35.37 | 208.59±14.56 | 2.83 | 0.001 |
| 12a-hydroxylase | CYP8B1 | NM_004391.1 | 1.01±0.30 | 2.21±0.16 | 2.18 | 0.002 |
| Oxysterol 7a-hydroxylase | CYP7B1 | NM_004820.2 | 1.66±0.22 | 1.81±0.20 | 1.09 | 0.679 |
| Bile acid CoA:amino acid N-acyltransferase | BAAT | NM_001701.2 | 110.43±25.06 | 113.72±14.98 | 1.03 | 0.909 |
| Bile acyl-CoA synthetase | BACS | NM_012254.1 | 12.98±1.86 | 21.30±2.39 | 1.64 | 0.052 |
| Transport proteins | ||||||
| Na+-taurocholate cotransporting polypeptide | NTCP | NM_003049.1 | 50.26±19.86 | 263.57±16.96 | 5.24 | 0.000 |
| Organic anion transport protein B1 | OATP1B1 | NM_006446.2 | 2.74±1.61 | 9.37±1.46 | 3.42 | 0.018 |
| Organic anion transport protein B3 | OATP1B3 | NM_019844.1 | 2.66±0.80 | 7.20±0.99 | 2.71 | 0.014 |
| Bile salt export protein | BSEP | NM_003742.2 | 1.85±0.13 | 1.34±0.11 | 0.72 | 0.017 |
| Regulation proteins | ||||||
| Farnesoid X receptor | FXR | NM_005123.1 | 7.89±0.48 | 9.14±0.83 | 1.16 | 0.368 |
| Small heterodimer peptide | SHP | NM_021969.1 | 19.66±7.19 | 20.27±3.16 | 1.03 | 0.928 |
| Hepatocyte nuclear factor 4 alpha | HNF4A | NM_000457.3 | 2.44±0.39 | 3.63±0.24 | 1.49 | 0.020 |
| Fibroblast growth factor receptor 4 | FGFR4 | NM_002011.3 | 0.88±0.09 | 2.23±0.31 | 2.53 | 0.021 |
| Klotho beta-like | KLB | NM_175737.2 | 10.65±2.41 | 4.88±0.45 | 0.46 | 0.003 |
*Patient information and data characterisation were described previously (Liu et al 20).
†Mean±SEM.