Top associated variants in the overall cohort of European alcoholic chronic pancreatitis patients
| SNP ID | Locus | Gene | Counted allele | MAF | p Value | OR (95% CI) |
| rs545634 | 1p36.21 | CTRC | A | 0.12 | 2.8×10–22 | 1.83 (1.63 to 2.06) |
| rs146437551 | 5q32 | SPINK1 | G | 0.013 | 3.3×10–15 | 3.82 (2.79 to 5.22) |
| rs2855983 | 7q34 | PRSS1-PRSS2 | G | 0.392 | 5.5×10–40 | 1.84 (1.69 to 2.00) |
| rs8055167 | 16q23.1 | CTRB1-CTRB2 | C | 0.28 | 4.2×10–9 | 1.35 (1.23 to 1.49) |
| rs12688091 | Xq22.3 | CLDN2-MORC4 | G | 0.31 | 9.9×10–33 | 2.57 (2.22 to 2.98) |
Results confirmed CLDN2-MORC4, CTRC, PRSS1-PRSS2 and SPINK1 as risk loci and identified a new locus in CTRB1-CTRB2. Data on linkage disequilibrium of the variants with previously reported risk variants in these loci are given in online supplementary table S3.
ID, identification; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.