Table 1

Correlations between expression of genes encoding chemokines and immune cell markers in CRC specimens (n=62)*

CD8T-betIRF-1IL-17CXCR5Foxp3
Spearman rP valueSpearman rP valueSpearman rP valueSpearman rP valueSpearman rP valueSpearman rp Value
CCL2 0.3960 0.0020 0.4100 0.0010 0.4250 0.0010 0.00600.96600.18800.1470 0.4620 <0.0001
CCL3 0.4036 0.0015 0.12470.3468 0.3205 0.0133 −0.22300.0890−0.05600.67300.15190.2509
CCL4 0.3454 0.0069 0.01620.90210.06870.6017−0.07000.5960−0.04400.7370−0.05330.6857
CCL5 0.6544 <0.0001 0.4252 0.0007 0.5578 <0.0001 −0.03000.81800.27500.03300.33990.0079
CCL7 0.3258 0.0104 0.07360.57300.26130.0420−0.00100.9930−0.02300.86000.12440.3396
CCL8 0.4632 0.0002 0.13330.30560.29690.0202−0.07200.58200.08800.50000.20380.1152
CCL11 0.3410 0.0080 0.3620 0.0040 0.4680 <0.0001 0.06200.63700.15600.2330 0.5540 <0.0001
CCL13 0.4097 0.0010 0.13640.2944 0.3265 0.0102 −0.02400.85200.20400.11500.17640.1739
CCL14-15 0.02300.86100.10200.5340−0.03100.8110 0.3460 0.0060 −0.19500.1330−0.08200.5280
CCL17 0.3234 0.0110 0.18340.1571 0.4450 0.0003 0.3000 0.0190 0.23100.07400.26460.0393
CCL18 0.24200.0610 0.3500 0.0060 0.3110 0.0150 −0.07100.58700.20900.10600.23100.0730
CCL19 0.5270 0.0010 0.5900 <0.0001 0.5270 <0.0001 0.00200.9880 0.5380 <0.0001 0.4890 0.0001
CCL20 −0.25280.0493−0.20510.1128−0.09330.4743 0.4440 0.0003 −0.15100.2450−0.12970.3192
CCL21 0.4070 0.0010 0.5560 <0.0001 0.4770 <0.0001 −0.18900.14500.19700.1270 0.5900 <0.0001
CCL22 0.3754 0.0029 0.4432 0.0003 0.6803 <0.0001 0.15700.2280 0.3550 0.0050 0.7033 <0.0001
CCL23 0.3510 0.0050 0.12700.3280 0.3410 0.0070 −0.09400.47200.11200.39200.16400.2070
CCL24 −0.10500.12300.13500.30100.26200.04100.05400.6780−0.05600.66600.06600.6160
CCL25 0.21740.09230.25410.04820.17780.1703 0.3830 0.0020 0.15800.22400.22260.0847
CCL26 0.13500.30100.21900.0890 0.3010 0.0180 0.04500.72800.21700.09300.17800.1700
CCL27 0.01100.24600.04100.75300.01100.9310 0.4180 0.0010 0.16300.21100.11200.3900
CCL28 −0.03200.39300.01100.9310−0.03200.8070 0.3570 0.0050 −0.04500.7280−0.12900.3200
CXCL3 −0.18500.1250−0.03300.8000−0.18500.1540 0.3790 0.0030 0.04200.7490−0.20300.1170
CXCL9 0.5509 <0.0001 0.4138 0.0010 0.5125 <0.0001 0.15900.2260 0.3910 0.0020 0.3458 0.0068
CXCL10 0.4268 0.0006 0.28670.02510.18350.15690.16700.19700.25600.04600.14310.2711
CXCL11 0.20750.10850.23610.0669 0.3708 0.0033 0.12000.35700.20600.11100.14360.2697
CXCL12 0.5330 <0.0001 0.3592 0.0045 0.5795 <0.0001 −0.26500.03900.20600.1120 0.4887 0.0001
CXCL13 0.4810 0.0001 0.6110 <0.0001 0.4270 0.0010 0.11100.3920 0.5760 <0.0001 0.5090 <0.0001
CXCL14 0.08000.56100.08100.5550 0.4150 0.0020 0.21300.11800.13600.32400.27400.0430
CXCL16 0.28640.02520.15620.2293 0.4231 0.0007 0.00400.97400.08600.51100.20460.1138
CX3CL1 0.27030.0351 0.3134 0.0139 0.5272 <0.0001 −0.20100.12000.01900.8870 0.4085 0.0011
  • *Significant correlation coefficients ≥0.3 are indicated in bold.

  • CRC, colorectal cancer; IL, interleukin.