High quality: Further research is very unlikely to change our confidence in the estimate of effect |
The trade-offs: Taking into account the estimate size of the effect for main outcomes, the confidence limits around those estimates and the relative value placed on each outcome |
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate |
The quality of the evidence
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Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate |
Translation of the evidence into practice in a particular setting: Taking into consideration important factors that could be expected to modify the size of expected effects |
Very low quality: Any estimate of effect is very uncertain |
Uncertainty about the baseline risk for the population of interest
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