Table 1

Patient demographics of pilot and validation Cytosponge cohorts

ControlsCasesPilotValidation
CharacteristicPilot cohortValidation cohortp ValuePilot cohortValidation cohortp Value(Controls vs cases)(Controls vs cases)
(n=10)(n=129)(n=20)(n=149)p Valuep Value
Age (years, median (IQR))48.0 (39.0–61.0)55.0 (43.0–63.0)0.298566.0 (58.0–75.0)65.0 (56.0–72.0)0.47710.003<0.0001
Gender (n (%))
Female7 (70.0)72 (55.8)0.58846 (30.0)27 (18.1)0.33810.09<0.0001
Male3 (30.0)57 (44.2)14 (70.0)122 (81.9)
Ethnicity (n (%))0.46540.66110.280.2149
White British9 (90.0)113 (87.6)19 (95)139 (93.3)
Other white background011 (8.5)1 (5)5 (3.4)
Asian1 (10.0)2 (1.6)05 (3.4)
African02 (1.6)00
Other01 (0.8)00
Body mass index (kg/m2, median (IQR))27.7 (24.0–29.2)27.4 (24.5–30.4)0.653128.3 (25.2–29.9)28.4 (25.7–30.8)0.61430.670.106
Waist:hip (median (IQR))0.87 (0.81–0.88)0.87 (0.82–0.94)0.52270.92 (0.90–0.95)0.95 (0.92–0.99)0.067540.002<0.0001
Hiatus hernia3 (30%)46 (35.7%)0.972217 (85%)118 (79.2%)0.75570.009<0.0001
Barrett’s length
C (cm)3.0 (0.4–6.3)2.0 (1.0–5.0)0.8188
M (cm)5.0 (3.0–7.0)4.0 (3.0–7.0)0.7306