Univariate and multivariate analyses
| Variable | Univariate analysis* | Multivariate analysis | ||
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Variceal rebleeding | ||||
| Allocation groups (EBL+drug vs TIPS)† | 3.32 (1.19 to 9.27) | 0.008 | ||
| Mortality | ||||
| HBV-DNA-positive (yes vs no)† | 4.11 (1.20 to 14.07) | 0.026 | 3.78 (1.07 to 13.37) | 0.039 |
| Child-Pugh score (per one point increase) | 1.62 (1.05 to 2.48) | 0.028 | ||
| MELD score (per one point increase) | 1.16 (0.99 to 1.35) | 0.060 | ||
| International normalised ratio† | 4.85 (1.26 to 18.66) | 0.022 | 6.39 (1.59 to 25.62) | 0.009 |
| Serum albumin (per one g/L decrease)† | 1.12 (0.97 to 1.28) | 0.056 | 1.17 (1.02 to 1.35) | 0.021 |
| Overt hepatic encephalopathy | ||||
| Child-Pugh score (per one point increase) | 1.44 (0.95 to 2.19) | 0.090 | ||
| MELD score (per one point increase)† | 1.18 (1.01 to 1.37) | 0.042 | 1.17 (1.01 to 1.37) | 0.043 |
| Ascites (yes vs no)† | 3.44 (0.88 to 13.41) | 0.076 | ||
| International normalised ratio | 4.09 (1.04 to 16.12) | 0.044 | ||
| Creatinine (per one µmol/L increased) | 1.06 (1.03 to 1.16) | 0.002 | ||
| Portal vein recanalisation | ||||
| MELD score (per one point increase)† | 1.19 (1.03 to 1.37) | 0.016 | ||
| International normalised ratio† | 3.30 (0.95 to 11.44) | 0.060 | ||
| SMV thrombosis (no vs yes)† | 4.86 (2.12 to 10.99) | <0.001 | 3.32 (1.40 to 7.86) | 0.006 |
| Treatment (TIPS vs EBL+drug)† | 3.92 (1.93 to 7.96) | <0.001 | 2.93 (1.37 to 6.28) | 0.006 |
*Only variables with a p value <0.1 in the univariate analysis are shown. Variables selected into the univariate analysis were allocation groups, gender, age, aetiology of cirrhosis, HBV-DNA positive, Child-Pugh class, Child-Pugh score, MELD score, MELD-Na score, interval from index bleeding to randomisation, presentation as acute bleeding, location of varices at index gastroscopy, grade of oesophageal varices, ascites, hydrothorax, previous hepatic encephalopathy, previous bleeding, haemoglobin, serum albumin, serum total bilirubin, international normalised ratio, serum creatinine, stage of PVT (acute or chronic), degree of PVT, site of PVT, extent of PVT, portal cavernoma and prothrombotic disorders.
†Variables introduced in multivariable analysis.
EBL, endoscopic band ligation; MELD, Model for End-Stage Liver Disease; PVT, portal vein thrombosis; SMV, superior mesenteric vein; TIPS, transjugular intrahepatic portosystemic shunt.