Table 2

Diagnostic accuracy of optical diagnosis of T1 CRC (ie, non-invasive vs invasive LNPCPs) and T1 CRC with deep submucosal invasion (ie, endoscopically resectable vs endoscopically unresectable LNPCPs)

Optical diagnosis of T1 CRC* (ie, non-invasive vs invasive LNPCPs)No. of LNPCPs (disease positives)340 (47)
Agreement (95% CI)92.1 (88.9 to 94.8)
Sensitivity (95% CI)78.7 (64.3 to 89.3)
Specificity (95% CI)94.2 (90.9 to 96.6)
Positive predictive value (95% CI)68.5 (57.3 to 77.9)
Negative predictive value (95% CI)96.5 (94.1 to 98.0)
Optical diagnosis of T1 CRC with deep invasion†
(ie, endoscopically resectable vs endoscopically unresectable LNPCPs)
No. of LNPCPs (disease positives)334 (30)
Agreement (95% CI)95.8 (93.4 to 97.9)
Sensitivity (95% CI)63.3 (43.9 to 80.1)
Specificity (95% CI)99.0 (97.1 to 100.0)
Positive predictive value (95% CI)86.4 (66.5 to 95.3)
Negative predictive value (95% CI)96.5 (94.5 to 97.7)
  • *Non-invasive (adenoma, sessile serrated adenoma or traditional serrated adenoma) vs invasive (T1 CRC or ≥T2 CRC) LNPCPs.

  • †Non-invasive or superficial submucosal invasion (adenoma, sessile serrated adenoma, traditional serrated adenoma or T1 CRC with superficial invasion) vs deep invasion (T1 CRC with deep invasion or ≥T2 CRC). T1 CRCs in which invasion depth could not be evaluated were excluded from this analysis.

  • CRC, colorectal cancer; LNPCP, large non-pedunculated colorectal polyp.