Efficacy of each markers of inflammation in predicting development of colorectal neoplasia after adjusting for other significant predictors
| Inflammation severity (Median number of colonoscopies) | HR (95% CI) | P value |
| Endoscopic | ||
| In last procedure only (1) | 1.0 (0.8 to 1.3) | 1.0 |
| Mean severity in preceding | ||
| 3 years (2) | 1.4 (1.0 to 1.8) | 0.02 |
| 5 years (3) | 1.5 (1.1 to 2.0) | 0.007 |
| 10 years (4) | 1.7 (1.2 to 2.4) | 0.001 |
| All episodes (6) | 1.9 (1.3 to 2.6) | 2.3e-04 |
| Max severity in preceding | ||
| 3 years(2) | 1.0 (0.8 to 1.2) | 0.9 |
| 5 years(3) | 1.1 (0.9 to 1.4) | 0.4 |
| 10 years (4) | 1.3 (1.0 to 1.7) | 0.02 |
| All episodes(6) | 1.4 (1.1 to 1.8) | 0.003 |
| Persistency in preceding | ||
| 3 years (2) | 1.3 (1.1 to 1.6) | 0.01 |
| 5 years (3) | 1.4 (1.1 to 1.8) | 0.001 |
| 10 years (4) | 1.6 (1.2 to 2.0) | 4.1e-0.4 |
| All episodes (6) | 1.8 (1.4 to 2.4) | 1.1e-05 |
| Histological | ||
| In last procedure only (1) | 0.9 (0.7 to 1.2) | 0.5 |
| Mean severity in preceding | ||
| 3 years (2) | 1.5 (1.1 to 2.1) | 0.01 |
| 5 years (3) | 2.2 (1.6 to 3.1) | 2.4e-06 |
| 10 years (4) | 2.8 (1.9 to 4.1) | 5.8e-08 |
| All episodes (6) | 3.1 (2.1 to 4.5) | 4.8e-09 |
| Max severity in preceding | ||
| 3 years (2) | 1.1 (0.8 to 2.4) | 0.6 |
| 5 years (3) | 1.4 (1.1 to 1.8) | 0.01 |
| 10 years (4) | 1.7 (1.3 to 2.2) | 7.0e-05 |
| All episodes (6) | 1.8 (1.4 to 2.4) | 4.7e-06 |
| Persistency in preceding | ||
| 3 years (2) | 1.5 (1.1 to 1.9) | 0.005 |
| 5 years (3) | 1.9 (1.4 to 2.6) | 9.5e-06 |
| 10 years (4) | 2.2 (1.6 to 3.0) | 7.3e-07 |
| All episodes (6) | 2.4 (1.7 to 3.3) | 1.2e–07 |
All HRs presented are per 1-unit increase in each inflammatory score. For mean and maximal severity, each 1-unit increase represents increments from quiescent to mild (0–1), mild to moderate (1–2) or moderate to severe (2–3) active inflammation. For persistency, 1-unit increase represents 33.3% increase in proportion of surveillance episodes with active inflammation of any severity (ie, 0=0%, 1=33.3%, 2=66.6% and 3=100%). The median number of surveillance procedures performed in preceding 3-year, 5-year, 10-year period for each episode was 2 (IQR, 2–3), 3 (IQR, 2–4) and 4 (IQR, 2–5), respectively. Statistically significant variables are highlighted in bold.