Table 4

Final multivariate model showing predictors associated with colorectal neoplasia

VariablesHR (95% CI)P value
Cumulative inflammatory burden
Endoscopic* 2.1 (1.5 to 2.9) <0.001
Histological* 2.1 (1.4 to 3.0) <0.001
Macroscopic features of chronicity
Scarring only1.4 (0.8 to 2.4)0.3
Tubular, featureless or shortened colon 1.8 (1.1 to 2.9) 0.03
Postinflammatory polyps1.2 (0.8 to 1.8)0.4
Colonic stricture 3.2 (1.3 to 8.0) 0.01
Chromoendoscopy1.0 (0.6 to 1.7)1.0
Primary sclerosing cholangitis 2.3 (1.1 to 4.7) 0.02
Age (at colonoscopy) 1.02 (1.00 to 1.04) 0.03
Average number of biopsies 1.14 (1.08 to 1.20) <0.001
Average surveillance interval 0.93 (0.91 to 0.96) <0.001
  • *HR per 10-unit increase in cumulative inflammatory burden (equivalent of 10, 5 or 3.3 years of continuous mild, moderate or severe active disease, respectively). Statistically significant variables are highlighted in bold.