Table 2

Correlation between key gut microbial taxa and bile acids in CC-treated mice

LCA CDCA DCA HDCA UDCA CA HCA αMCA βMCA ωMCA TLCA GCA TCDCA TDCA TUDCA TCA TαMCA TβMCA TωMCA
Faeces
Barnesiella 0.160.240.110.16−0.010.090.140.010.33−0.37−0.24−0.32−0.25−0.37−0.42−0.43−0.50−0.27
Turicibacter 0.460.360.30 0.60 0.45 0.69 0.40−0.280.490.110.08−0.190.010.16−0.260.07−0.080.24
Lactobacillus 0.89 0.67 0.62 0.93 0.82 0.91 0.81 0.11 0.72 0.010.44−0.170.210.13−0.290.08−0.170.13
Akkermansia 0.04−0.260.04−0.050.130.08−0.07−0.310.18−0.05−0.09−0.07−0.240.180.040.140.050.25
 Christensenellaceae−0.22 −0.59 −0.42−0.28−0.13−0.30−0.48−0.17−0.30−0.40−0.19−0.10−0.490.08−0.06−0.040.140.05
Roseburia −0.26−0.30−0.27−0.17−0.22−0.02−0.11−0.340.07 0.59 −0.19−0.030.02−0.020.230.15−0.010.00
 Lachnospiriraceae−0.12 −0.60 −0.68 −0.18−0.03−0.31−0.460.22 −0.75 −0.160.170.33−0.260.300.290.23 0.58 −0.02
Delftia 0.040.300.39−0.030.04−0.060.160.25−0.030.020.360.140.410.010.090.070.010.08
Anaerostipes 0.84 0.500.39 0.82 0.75 0.79 0.66 0.09 0.56 −0.120.43−0.120.020.14−0.230.07−0.130.07
 Erysipelotrichaceae−0.13−0.010.18−0.09−0.10−0.180.000.160.13−0.35−0.38−0.45−0.13−0.30−0.39−0.37−0.32−0.23
Bifidobacterium −0.340.400.45−0.24−0.40−0.290.060.230.050.01−0.34−0.300.30−0.47−0.27−0.40−0.41−0.26
Plasma
Barnesiella −0.480.35−0.44−0.16 0.62 0.350.34 0.55 −0.040.00−0.21−0.010.020.170.18−0.18
Turicibacter −0.07−0.080.070.47−0.190.08−0.02−0.14−0.150.130.170.050.090.200.040.22
Lactobacillus 0.08−0.120.05 0.66 −0.020.350.210.08−0.020.150.320.090.300.430.270.34
Akkermansia 0.66 −0.290.03−0.14−0.29−0.28−0.35−0.41 −0.58 0.34 0.56 0.54 0.300.05−0.02−0.14
 Christensenellaceae 0.70 0.010.41−0.19−0.03−0.25−0.21−0.22−0.200.400.49 0.63 0.23−0.02−0.07−0.12
Roseburia 0.03−0.17−0.320.01−0.47−0.32−0.39−0.48−0.37−0.100.03−0.10−0.04−0.18−0.150.14
 Lachnospiriraceae0.450.280.350.120.07−0.31−0.21−0.230.19−0.21−0.13−0.07−0.30−0.39−0.410.03
Delftia −0.15−0.230.300.04−0.080.310.340.300.470.160.110.040.260.320.400.19
Anaerostipes 0.04−0.04−0.190.430.100.11−0.01−0.01−0.25−0.080.100.000.040.14−0.010.05
 Erysipelotrichaceae 0.74 −0.410.31−0.30−0.19−0.17−0.18−0.24−0.340.43 0.57 0.58 0.320.090.05−0.26
Bifidobacterium −0.51−0.35−0.09−0.38−0.210.060.090.130.080.06−0.19−0.110.010.090.20−0.19
  • Pearson’s r highlighted in bold are statistically significant.

  • CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; GLCA, glycolithocholic acid; GUDCA, glycoursodeoxycholic acid; HCA, hyocholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; TCA, tauro-cholic acid; TDCA, tauro-deoxycholic acid; TLCA, tauro-lithocholic acid; TUDCA, tauro-ursodeoxycholic acid; TαMCA, tauro-α-murocholic acid; TβMCA, tauro-β-murocholic acid; TωMCA, tauro-ω-murocholic acid; UDCA, ursodeoxycholic acid; αMC, α-murocholic acid; βMCA, β-murocholic acid; ωMCA, ω-murocholic acid.