Table 2

Correlation between key gut microbial taxa and bile acids in CC-treated mice

	LCA	CDCA	DCA	HDCA	UDCA	CA	HCA	αMCA	βMCA	ωMCA	TLCA	GCA	TCDCA	TDCA	TUDCA	TCA	TαMCA	TβMCA	TωMCA
Faeces
Barnesiella		0.16	0.24	0.11	0.16	−0.01	0.09	0.14	0.01	0.33	−0.37	−0.24	−0.32	−0.25	−0.37	−0.42	−0.43	−0.50	−0.27
Turicibacter		0.46	0.36	0.30	0.60	0.45	0.69	0.40	−0.28	0.49	0.11	0.08	−0.19	0.01	0.16	−0.26	0.07	−0.08	0.24
Lactobacillus		0.89	0.67	0.62	0.93	0.82	0.91	0.81	0.11	0.72	0.01	0.44	−0.17	0.21	0.13	−0.29	0.08	−0.17	0.13
Akkermansia		0.04	−0.26	0.04	−0.05	0.13	0.08	−0.07	−0.31	0.18	−0.05	−0.09	−0.07	−0.24	0.18	0.04	0.14	0.05	0.25
Christensenellaceae		−0.22	−0.59	−0.42	−0.28	−0.13	−0.30	−0.48	−0.17	−0.30	−0.40	−0.19	−0.10	−0.49	0.08	−0.06	−0.04	0.14	0.05
Roseburia		−0.26	−0.30	−0.27	−0.17	−0.22	−0.02	−0.11	−0.34	0.07	0.59	−0.19	−0.03	0.02	−0.02	0.23	0.15	−0.01	0.00
Lachnospiriraceae		−0.12	−0.60	−0.68	−0.18	−0.03	−0.31	−0.46	0.22	−0.75	−0.16	0.17	0.33	−0.26	0.30	0.29	0.23	0.58	−0.02
Delftia		0.04	0.30	0.39	−0.03	0.04	−0.06	0.16	0.25	−0.03	0.02	0.36	0.14	0.41	0.01	0.09	0.07	0.01	0.08
Anaerostipes		0.84	0.50	0.39	0.82	0.75	0.79	0.66	0.09	0.56	−0.12	0.43	−0.12	0.02	0.14	−0.23	0.07	−0.13	0.07
Erysipelotrichaceae		−0.13	−0.01	0.18	−0.09	−0.10	−0.18	0.00	0.16	0.13	−0.35	−0.38	−0.45	−0.13	−0.30	−0.39	−0.37	−0.32	−0.23
Bifidobacterium		−0.34	0.40	0.45	−0.24	−0.40	−0.29	0.06	0.23	0.05	0.01	−0.34	−0.30	0.30	−0.47	−0.27	−0.40	−0.41	−0.26
Plasma
Barnesiella	−0.48	0.35	−0.44	−0.16	0.62	0.35		0.34	0.55	−0.04			0.00	−0.21	−0.01	0.02	0.17	0.18	−0.18
Turicibacter	−0.07	−0.08	0.07	0.47	−0.19	0.08		−0.02	−0.14	−0.15			0.13	0.17	0.05	0.09	0.20	0.04	0.22
Lactobacillus	0.08	−0.12	0.05	0.66	−0.02	0.35		0.21	0.08	−0.02			0.15	0.32	0.09	0.30	0.43	0.27	0.34
Akkermansia	0.66	−0.29	0.03	−0.14	−0.29	−0.28		−0.35	−0.41	−0.58			0.34	0.56	0.54	0.30	0.05	−0.02	−0.14
Christensenellaceae	0.70	0.01	0.41	−0.19	−0.03	−0.25		−0.21	−0.22	−0.20			0.40	0.49	0.63	0.23	−0.02	−0.07	−0.12
Roseburia	0.03	−0.17	−0.32	0.01	−0.47	−0.32		−0.39	−0.48	−0.37			−0.10	0.03	−0.10	−0.04	−0.18	−0.15	0.14
Lachnospiriraceae	0.45	0.28	0.35	0.12	0.07	−0.31		−0.21	−0.23	0.19			−0.21	−0.13	−0.07	−0.30	−0.39	−0.41	0.03
Delftia	−0.15	−0.23	0.30	0.04	−0.08	0.31		0.34	0.30	0.47			0.16	0.11	0.04	0.26	0.32	0.40	0.19
Anaerostipes	0.04	−0.04	−0.19	0.43	0.10	0.11		−0.01	−0.01	−0.25			−0.08	0.10	0.00	0.04	0.14	−0.01	0.05
Erysipelotrichaceae	0.74	−0.41	0.31	−0.30	−0.19	−0.17		−0.18	−0.24	−0.34			0.43	0.57	0.58	0.32	0.09	0.05	−0.26
Bifidobacterium	−0.51	−0.35	−0.09	−0.38	−0.21	0.06		0.09	0.13	0.08			0.06	−0.19	−0.11	0.01	0.09	0.20	−0.19

Pearson’s r highlighted in bold are statistically significant.
CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; GLCA, glycolithocholic acid; GUDCA, glycoursodeoxycholic acid; HCA, hyocholic acid; HDCA, hyodeoxycholic acid; LCA, lithocholic acid; TCA, tauro-cholic acid; TDCA, tauro-deoxycholic acid; TLCA, tauro-lithocholic acid; TUDCA, tauro-ursodeoxycholic acid; TαMCA, tauro-α-murocholic acid; TβMCA, tauro-β-murocholic acid; TωMCA, tauro-ω-murocholic acid; UDCA, ursodeoxycholic acid; αMC, α-murocholic acid; βMCA, β-murocholic acid; ωMCA, ω-murocholic acid.