Table 1

Colon biopsy discovery cohorts (in silico)—IBD predictive gene signatures and patient cohorts used in the immune contribution analysis and cell-type meta-analysis, respectively

Signature/cohort*Genes in signatureIBD typeResponse†GEO datasetAssociated publication
RNR
UC-A20UC816GSE14580 10
UC-B
UC-B-knn
IRRAT
20
19
29
UC1210GSE12251 10 14 15
UC-AB‡53UC8
12
16
10
GSE14580
GSE12251
10
CDc20CD127GSE16879 11
  • *Details of the previously reported gene signatures, grouped according to the cohort in which they were identified to be predictive of infliximab response. Underlined names being used as cohort names.

  • †R/NR number in each cohort

  • ‡Signature defined from overlap between cohort UC-A and UC-B.

  • CDc, Crohn’s disease cohort; NR, non-responder; R, responder.