Table 1

Study populations

VariableDiscoveryEuropean replication cohort n=6722 (diverticular disease (DD) 3893, diverticula-free controls 2829)
UK Biobank—500 000
GWAS (n=4 51 052)
Germany
(North)
(n=2842)
Germany
(West)
(n=320)
Austria
(Vienna)
(n=1151)
Austria
(Oberndorf)
(n=1378)
Lithuania
(n=773)
Sweden
(n=258)
DD/controls
31 917/419 135
DD/controls
2171/671
DD/controls
227/93
DD/controls
578/573
DD/controls
387/991
DD/controls
479/295
DD/controls
51/207
Male (%)Case46.546.954.660.457.443.039.2
Control45.754.748.458.148.539.537.2
Age (years)Case72 (68–76)68 (59–75)67 (58–75)68 (61–74)65 (57–72)68 (61–74)62 (56–67)
Control68 (60–73)62 (57–68)59 (44–64)64 (56–72)59 (53–67)57 (46–67)53 (44–61)
BMICase27.9 (25–31)26.9 (24–30)27.1 (24–30)28.1 (25–30)28.0 (23–33)28.6 (26–32)24.0 (22–27)
Control26.6 (24–29)25.7 (23–28)27.0 (24–30)27.4 (24–30)27.3 (21–33)26.6 (23–30)25.0 (22–28)
  • Overview of the study populations used in the discovery and replication cohorts. All quantitative measures (age, BMI) are provided as medians and IQRs. Patients from the Germany/North cohort were recruited through the PopGen biobank as described previously.53

  • BMI, body mass index; GWAS, genome-wide association study.