Study populations
| Variable | Discovery | European replication cohort n=6722 (diverticular disease (DD) 3893, diverticula-free controls 2829) | ||||||
| UK Biobank—500 000 GWAS (n=4 51 052) | Germany (North) (n=2842) | Germany (West) (n=320) | Austria (Vienna) (n=1151) | Austria (Oberndorf) (n=1378) | Lithuania (n=773) | Sweden (n=258) | ||
| DD/controls 31 917/419 135 | DD/controls 2171/671 | DD/controls 227/93 | DD/controls 578/573 | DD/controls 387/991 | DD/controls 479/295 | DD/controls 51/207 | ||
| Male (%) | Case | 46.5 | 46.9 | 54.6 | 60.4 | 57.4 | 43.0 | 39.2 |
| Control | 45.7 | 54.7 | 48.4 | 58.1 | 48.5 | 39.5 | 37.2 | |
| Age (years) | Case | 72 (68–76) | 68 (59–75) | 67 (58–75) | 68 (61–74) | 65 (57–72) | 68 (61–74) | 62 (56–67) |
| Control | 68 (60–73) | 62 (57–68) | 59 (44–64) | 64 (56–72) | 59 (53–67) | 57 (46–67) | 53 (44–61) | |
| BMI | Case | 27.9 (25–31) | 26.9 (24–30) | 27.1 (24–30) | 28.1 (25–30) | 28.0 (23–33) | 28.6 (26–32) | 24.0 (22–27) |
| Control | 26.6 (24–29) | 25.7 (23–28) | 27.0 (24–30) | 27.4 (24–30) | 27.3 (21–33) | 26.6 (23–30) | 25.0 (22–28) | |
Overview of the study populations used in the discovery and replication cohorts. All quantitative measures (age, BMI) are provided as medians and IQRs. Patients from the Germany/North cohort were recruited through the PopGen biobank as described previously.53
BMI, body mass index; GWAS, genome-wide association study.