Table 1

Univariate and multivariate analysis with Cox proportional hazard regression model (TMA cohort)

VariablesUnivariate analysisMultivariate analysis
HR (95% CI)P valuesHR (95% CI)P values
TREG density (no./mm2) (<median vs ≥median)2.4 (1.4 to 4.1) 0.001 3.6 (2.0 to 6.6) 2.9E-05
TRM density (no./mm2) (<median vs ≥median)0.3 (0.2 to 0.5) 1.7E-06 0.2 (0.1 to 0.4) 6.0E-07
TNM stage (I/II/III/IV)1.5 (1.2 to 2.1) 0.004 1.1 (0.8 to 1.6)0.597
Grade (1/2/3/4)1.3 (0.9 to 1.8)0.1501.1 (0.8 to 1.6)0.648
Tumour size (cm) (<median vs ≥median)1.6 (1.0 to 2.7)0.0681.5 (0.9 to 2.6)0.170
AFP level (μg/mL) (<median vs ≥median)1.7 (1.0 to 2.8) 0.045 1.8 (1.0 to 3.2)0.056

  • AFP, alpha-fetoprotein; TMA, tissue-microarray; TNM, tumour, node, metastases.