Table 3

Characteristics of German–Swiss cohort of alcohol misusers

Total n=1798Controls (no liver injury)
n=864 (48.1%)
Cases (cirrhosis)
n=934 (51.9%)
(p values)
 Age (years)51±1145±1056±10<0.0001
 Sex (women)386 (22)118 (14)268 (29)<0.0001
 BMI (kg/m2)25.6±4.624.9±4.926.3±5.0<0.0001
 Diabetes mellitus (yes/no/NA, % yes)209/1199/390 (15)13/612/239 (2)196/587/151 (25)<0.0001
Frequency of AAT genotypes
 Pi*MZ genotype75 (4.17)17 (1.97)58 (6.21)<0.0001
 Pi*ZZ genotype4 (0.12)0 (0)4 (0.43)0.073*
 Pi*MS genotype†120 (6.77)47 (5.53)73 (7.92)0.046
 Pi*SS genotype†3 (0.17)1 (0.06)2 (0.11)0.390*
 Pi*SZ genotype†6 (0.34)0 (0)6 (0.65)0.019*
  • Cases were defined as alcohol misusers with cirrhosis whereas controls were defined as alcohol misusers without evidence of significant liver injury. Quantitative measures are shown as mean±SD or as an absolute count (n) and relative frequency (%).

  • *Fisher’s exact test.

  • †1772 subjects (98.6% of all subjects) were genotyped for presence of the Pi*S variant.

  • AAT, alpha1-antitrypsin; BMI, body mass index; NA, not available; Pi*MZ, heterozygous for the Pi*Z variant; Pi*ZZ, homozygous for the Pi*Z variant; Pi*MS, heterozygous for the Pi*S variant; Pi*SS, homozygous for the Pi*S variant; Pi*SZ, compound heterozygous for the Pi*S and the Pi*Z variant.