Table 2

Characteristics of the second non-alcoholic fatty liver disease (NAFLD) cohort

Total n=541Controls (stage F0)
n=256 (47.3%)
Cases (stage F4)
n=26 (4.8%)
(p values)
 Age (years)49±1447±1460±8<0.0001
 Sex (women)251 (46)110 (43)15 (58)0.150
 BMI (kg/m2)33±1033±1031±80.366
 Diabetes mellitus (yes/no/NA, % yes)146/366/29 (27)47/193/16 (18)8/13/5 (31)0.046
Frequency of Pi*Z allele
 Pi*Z heterozygous22 (4.1)6 (2.3)4 (15.4)0.007*
 Pi*Z homozygous2 (0.4)1 (0.4)1 (3.8)0.155*
  • Cases were defined as NAFLD patients with histological cirrhosis (stage F4), whereas controls were defined as NAFLD patients without histological evidence of fibrosis (stage F0). Quantitative measures are shown as mean±SD or as an absolute count (n) and relative frequency (%).

  • *Fisher’s exact test.

  • BMI, body mass index; NA, not available.