Table 2

Overview of currently available studies assessing the sensitivity and specificity of cross-sectional imaging for the detection of Crohn’s disease-associated strictures that use histopathology as a reference standard

Study IDStudy designPatients with stricture (n)Reference standard or comparatorRadiographic modalitySensitivity for stricture diagnosisSpecificity for stricture diagnosis
Ultrasound (US)Maconi et al 16 Prospective cohort

  • Mean age (years): 40

  • Female (%): 42

43Histopathology (resection)TUS100%63%
Kumar et al 15 Retrospective cohort

  • Mean age (years): 28

  • Female (%): 52

8Histopathology (resection)SICUS, with power DopplerSICUS 88%SICUS 88%
Onali et al 17 Prospective case–control

  • Mean age (years): 41

  • Female (%): 46

13Histopathology (resection)SICUSSICUS 92%SICUS 0%
Pallotta et al 18 Prospective cohort

  • Mean age (years): 38

  • Female (%): 43

40Histopathology (resection)SICUS
TUS		SICUS 97.5%
TUS 80%		SICUS 100%
TUS 75%
CTChiorean et al 24 Retrospective cohort

  • Median age (years): 35

  • Female (%): 61

31Histopathology (resection)CT enteroclysis92.3%38.9%
Pellino et al 26 Prospective cohort

  • Median age (years): 39

  • Female (%): 60

31Histopathology (resection)Hybrid positron emission tomography/CT enterography85%NR
Vogel et al 25 Retrospective cohort

  • Mean age (years): 39

  • Female (%): 64

18Histopathology (resection)CT enterography100%100%
MRIKumar et al 15 Retrospective cohort

  • Mean age (years): 31

  • Female (%): 35

8Histopathology (resection)MR enterography100%91%
Pellino et al 25 Prospective cohort

  • Median age (years): 39

  • Female (%): 60

31Histopathology (resection)Hybrid positron emission tomography/MR enterography85%NR
Pous-Serrano et al 28 Prospective cohort

  • Age (years): not provided

  • Female (%): 42

27Histopathology (resection)MR enterography75%96%
Sinha et al 34 Prospective cohort

  • Median age (years): 43

  • Female (%): 59

49Histopathology (resection)HR MR enterography86%95%

  • HR, high resolution; NR, not reported; SICUS, small intestinal contrast ultrasonography; TUS, transabdominal ultrasonography.