Table 1

Characteristics of the first non-alcoholic fatty liver disease (NAFLD) cohort

Total n=643Controls (stage F0)
n=362 (56.3%)
Cases (stage F4)
n=68 (10.6%)
(p values)
 Age (years)49±1446±1361±13<0.0001
 Sex (women)322 (50)165 (46)41 (60)0.026
 BMI (kg/m2)37±1236±1228±7<0.0001
 Diabetes mellitus (yes/no/NA, % yes)188/403/52 (32)84/265/13 (24)24/14/30 (63)<0.0001
Frequency of AAT genotypes
 Pi*MZ genotype36 (5.6)9 (2.5)9 (13.2)<0.0001
 Pi*ZZ genotype0 (0)0 (0)0 (0)NA
 Pi*MS genotype29 (4.5)14 (3.9)3 (4.4)0.740*
 Pi*SS genotype0 (0)0 (0)0 (0)NA
 Pi*SZ genotype0 (0)0 (0)0 (0)NA
  • Cases were defined as NAFLD patients with histological cirrhosis (stage F4), whereas controls were defined as NAFLD patients without histological evidence of fibrosis (stage F0). Quantitative measures are shown as mean±SD or as an absolute count (n) and relative frequency (%).

  • *Fisher’s exact test.

  • AAT, alpha1-antitrypsin; BMI, body mass index; NA, not available/applicable; Pi*MZ, heterozygous for the Pi*Z variant; Pi*ZZ, homozygous for the Pi*Z variant; Pi*MS, heterozygous for the Pi*S variant; Pi*SS, homozygous for the Pi*S variant; Pi*SZ, compound heterozygous for the Pi*S and the Pi*Z variant.