Characteristics of British–Irish cohort of alcohol misusers
| Total n=664 | Controls (no liver injury) n=347 (52.2%) | Cases (cirrhosis) n=317 (47.8%) | Significance (p values) | |
| Characteristics | ||||
| Age (years) | 51±11 | 49±10 | 53±10 | <0.0001 |
| Sex (women) | 180 (27) | 81 (23) | 99 (31) | 0.022 |
| BMI (kg/m2)~ | 24.7±2.5 | 24.7±2.3 | 24.6±2.6 | 0.901 |
| Diabetes mellitus (yes/no/NA, % yes)~ | – | – | – | NA |
| Frequency of AAT genotypes | ||||
| Pi*MZ genotype | 28 (4.22) | 9 (2.59) | 19 (5.99) | 0.029 |
| Pi*ZZ genotype* | 0 (0) | 0 (0) | 0 (0) | NA |
| Pi*MS genotype† | 61 (9.30) | 28 (8.16) | 33 (10.54) | 0.295 |
| Pi*SS genotype† | 2 (0.30) | 1 (0.29) | 1 (0.32) | 0.499‡ |
| Pi*SZ genotype† | 2 (0.30) | 1 (0.29) | 1 (0.32) | 0.499‡ |
Cases were defined as alcohol misusers with cirrhosis, whereas controls were defined as alcohol misusers without evidence of significant liver injury. Quantitative measures are shown as mean±SD or as an absolute count (n) and relative frequency (%).
*Patients with the Pi*ZZ genotype were excluded a priori.
†656 subjects (98.8% of all subjects) were genotyped for presence of the Pi*S variant.
‡Fisher’s exact test.
AAT, alpha1-antitrypsin; BMI, body mass index; NA, not applicable; Pi*MZ, heterozygous for the Pi*Z variant; Pi*ZZ, homozygous for the Pi*Z variant; Pi*MS, heterozygous for the Pi*S variant; Pi*SS, homozygous for the Pi*S variant; Pi*SZ, compound heterozygous for the Pi*S and the Pi*Z variant.
~ Subjects with diabetes and/or subjects with BMI >30 kg/m2 have been excluded.