Table 5

The expression and function of choline acetyltransferase, acetylcholinesterase and butyrylcholinesterase

Age groupAscendingDescendingRegion comparison (adult)
Choline acetyltransferase (ChAT)
 ChAT function (pmol/min/mg)35–60 years687±65 (8)567±83 (10)P value=0.64
≥70 years688±76 (10)890±71 (10)
Age comparisonP value=1.00P value=0.01
 ChAT expression (ng/mg)35–60 years12.1±2.0 (8)9.0±0.9 (9)P value=0.27
≥70 years12.2±1.1 (10)10.1±0.9 (10)
Age comparisonP value=1.00P value=0.90
 ChAT specific activity (pmol/ng/min)35–60 years67±11 (8)67±13 (9)P value=1.00
≥70 years63±10 (10)97±12 (10)
Age comparisonP value=1.00P value=0.21
Acetyl cholinesterase (AChE)
 AChE function (nmol/min/mg)35–60 years1045±379 (7)700±132 (8)P value =0.65
≥70 years451±160 (8)590±196 (7)
Age comparisonP value=0.21P value=0.98
 AChE expression (ng/mg)35–60 years3.8±1.0 (8)3.1±0.5 (8)P value=0.89
≥70 years2.7±0.6 (10)2.3±0.5 (10)
Age comparisonP value=0.63P value=0.80
 AChE specific activity (nmol/min/mg)35–60 years221±46 (7)251±20 (7)P value=0.96
≥70 years199±66 (8)207±37 (7)
Age comparisonP value=0.98P value=0.89
Butryl cholinesterase (BChE)
 BChE function (nmol/min/mg)35–60 years967±295 (7)620±103 (10)P value =0.42
≥70 years796±197 (9)556±75 (10)
Age comparisonP value=0.87P value=0.99
 BChE expression (ng/mg)35–60 years573±140 (8)325±84 (10)P value=0.16
≥70 years352±70 (10)292±45 (10)
Age comparisonP value=0.24P value=0.99
 BChE-specific activity (nmol/min/mg)35–60 years1.9±0.4 (7)3.2±0.8 (10)P value=0.50
≥70 years2.2±0.4 (9)2.6±0.7 (10)
Age comparisonP value=0.99P value=0.89
  • Assays were performed in muscle biopsies taken from patients undergoing resections of the ascending or descending colon. The n values are in parenthesis.