Clinical feature supportive of IgG4-SC or PSC | PSC | IgG4-SC |
Male sex | + | ++ |
Younger age | ++ | + |
Pancreatic mass or enlargement on CT | − | ++ |
Pancreatic ductal abnormalities | +/- | +++ |
Raised serum IgG4 | +/- | ++ |
Ampullary biopsy with >10 IgG4 plasma cells per high power field | − | +++ |
Liver/tissue biopsy with >10 IgG4 plasma cells per high power field | +/− | +++ |
Pancreatic exocrine insufficiency | − | ++ |
Other associated systemic fibrosclerotic disease | − | ++ |
Cholangiographic changes | ++ | ++ |
Presence of inflammatory bowel disease | ++ | +/− |
Improvement with steroid treatment | +/− | +++ |