Table 2

Clinical parameters in differentiating IgG4-related sclerosing cholangitis (IgG4-SC) from primary sclerosing cholangitis (PSC)

Clinical feature supportive of IgG4-SC or PSCPSCIgG4-SC
Male sex+++
Younger age+++
Pancreatic mass or enlargement on CT++
Pancreatic ductal abnormalities+/-+++
Raised serum IgG4+/-++
Ampullary biopsy with >10 IgG4 plasma cells per high power field+++
Liver/tissue biopsy with >10 IgG4 plasma cells per high power field+/−+++
Pancreatic exocrine insufficiency++
Other associated systemic fibrosclerotic disease++
Cholangiographic changes++++
Presence of inflammatory bowel disease+++/−
Improvement with steroid treatment+/−+++