GRADE—strength of evidence | GRADE—strength of recommendation |

High qualityFurther research is very unlikely to change our confidence in the estimate of effect | The trade-offsTaking into account the estimated size of the effect for main outcomes, the confidence limits around those estimates and the relative value placed on each outcome |

Moderate qualityFurther research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate | The quality of the evidence |

Low qualityFurther research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate | Translation of the evidence into practice in a particular settingTaking into consideration important factors that could be expected to modify the size of expected effects |

Very low qualityAny estimate of effect is very uncertain | Uncertainty about the baseline risk for the population of interest |