Table 3

Proportion of patients who were prescribed an antidepressant by depression status and developed Crohn’s disease or UC compared with those who did not use antidepressants and developed Crohn’s disease or UC

Major depressive disorder
(n=403 665)
Referent cohort
(n=5 323 986)
Treated with antidepressants
(n=356 331)
Not treated with antidepressants
(n=47 334)
P valuesTreated with antidepressants
(n=802 617)
Not treated with antidepressants
(n=4 521 369)
P values
Risk of Crohn’s disease0.05%0.07%0.07390.04%0.03%<0.0001
Risk of UC0.12%0.20%<0.00010.09%0.09%1.00