Multivariate analysis and combined model of clinicopathological factors, DDIR status, relapse-free and overall survival in OAC
| Relapse-free survival | Overall survival | |||||
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Multivariate model | ||||||
| DDIR positive | 0.61 | 0.38–0.98 | 0.042 | 0.52 | 0.31–0.88 | 0.015 |
| Clinical T stage (T1/2 v 3/4) | 1.08 | 0.56–2.09 | 0.810 | 1.05 | 0.55–2.03 | 0.876 |
| Clinical N stage (N0 v 1/2/3) | 1.67 | 1.04–2.67 | 0.033 | 1.51 | 1.94–2.42 | 0.088 |
| Differentiation (well/moderate vs poor) | 1.32 | 0.91–1.92 | 0.146 | 1.43 | 0.97–2.10 | 0.071 |
DDIR, DNA damage immune response; OAC, oesophageal adenocarcinoma.