GRADE—strength of evidence | GRADE—strength of recommendation |
High quality
Further research is very unlikely to change our confidence in the estimate of effect |
The trade-offs
Taking into account the estimated size of the effect for main outcomes, the confidence limits around those estimates and the relative value placed on each outcome |
Moderate quality
Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate | The quality of the evidence |
Low quality
Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate |
Translation of the evidence into practice in a particular setting
Taking into consideration important factors that could be expected to modify the size of expected effects |
Very low quality
Any estimate of effect is very uncertain | Uncertainty about the baseline risk for the population of interest |