Table 1

Allele frequency and genotype distribution of the PRSS1 c.486C>T (rs6666) variant in patients with CP and controls without pancreatic disease

Allele frequency
CTORP value95% CI
Total CP (n=223)298 (67%)148 (33%)0.670.0020.52 to 0.86
ACP (n=120)168 (70%)72 (30%)0.570.00070.42 to 0.79
NACP (n=103)130 (63%)76 (37%)0.780.140.57 to 1.09
Controls (n=296)339 (57%)253 (43%)
Genotype frequency
CCCTTTORPvalue95% CIHWE
Total CP (n=223)103 (46%)92 (41%)28 (13%)0.58
0.63
0.0025
0.06
0.41 to0.83
0.39 to 1.02
0.3
ACP (n=120)59 (49%)50 (42%)11 (9%)0.52
0.44
0.0022
0.0173
0.33 to0.79
0.22 to 0.87
0.9
NACP (n=103)44 (43%)42 (41%)17 (16%)0.66
0.87
0.08
0.64
0.42 to1.04
0.48 to 1.56
0.2
Controls (n=296)98 (33%)143 (48%)55 (19%)0.8
  • Genotype data were analysed, assuming dominant (shown in italics) or recessive models of inheritance for the minor T allele.

  • Calculations were performed using χ2 test (GraphPad Prism V.8).

  • ACP, alcoholic chronic pancreatitis; CP, chronic pancreatitis; HWE, Hardy-Weinberg disequilibrium; NACP, non-alcoholic chronic pancreatitis.