Table 1

Patient details and raw bifurcation counts

Patient ref	Disease	Age	Total crypts	CCO+ crypts	CCO− crypts	CCO partial crypts	Total bifurcation events	Type I bifurcation events (% of total)	Type II bifurcation events (% of total)	Type III bifurcation events (% of total)	Fission/fusion rate (per crypt per year) (95% CI)	Duration of fission/fusion (weeks) (95% CI)
1	None	79	4919	4086	497	336	7	5 (71.4%)	2 (28.6%)	0	0.009 (0.007 to 0.011)	3.9 (3.1 to 4.7)
2	None	60	3547	3424	70	53	3	3 (100%)	0	0	0.005 (0.001 to 0.009)	4.1 (1.3 to 6.8)
3	None	64	6958	6798	101	59	5	5 (100%)	0	0	0.002 (0.001 to 0.003)	9.1 (2.5 to 15.7)
4	FAP	67	6417	5910	287	220	44	41 (93.2%)	1 (2.3%)	2 (4.5%)	0.017 (0.013 to 0.021)	10.7 (8.1 to 13.2)
5	FAP	59	4095	3713	193	189	23	20 (87.0%)	3 (13.0%)	0	0.033 (0.024 to 0.042)	4.4 (3.2 to 5.7)
6	FAP	39	3085	3018	43	24	48	48 (100%)	0	0	0.010 (0.002 to 0.019)	40.7 (6.8 to 74.6)
7a	AFAP	64	5448	5213	148	87	54	50 (92.6%)	3 (5.6%)	1 (1.9%)	0.012 (0.008 to 0.017)	20.9 (13.3 to 28.6)
7b	AFAP	64	5065	4463	291	311	25	20 (80.0%)	3 (12.0%)	2 (8.0%)	0.012 (0.008 to 0.015)	11.0 (8.0 to 14.0)
8	AFAP	65	11 755	11 351	213	191	25	18 (72.0%)	0	7 (28.0%)	0.014 (0.010 to 0.018)	3.9 (2.8 to 5.1)
9	AFAP	61	4174	3641	282	251	27	20 (74.1%)	2 (7.4%)	5 (18.5%)	0.027 (0.021 to 0.034)	6.2 (4.7 to 7.7)
10	AFAP	60	2038	1962	52	24	16	14 (87.5%)	1 (6.3%)	1 (6.3%)	0.011 (0.004 to 0.019)	17.1 (6.3 to 28.0)
11a	IBD	66	272	256	15	1	3	3 (100%)	0	0	ND	ND
11b	IBD	66	402	378	21	3	1	1 (100%)	0	0	ND	ND
12	IBD	72	301	238	58	5	3	1 (33.3%)	0	2 (66.7%)	ND	ND
13	IBD	65	1245	1057	102	86	25	22 (88.0%)	2 (8.0%)	1 (4.0%)	ND	ND
14	None	42	2702	ND	ND	ND	ND	ND	ND	ND	0.020 (0.006 to 0.034)	ND
15	None	50	2878	ND	ND	ND	ND	ND	ND	ND	0.009 (0.001 to 0.017)	ND
16	None	50	2883	ND	ND	ND	ND	ND	ND	ND	0.015 (0.006 to 0.024)	ND
17	None	62	12 030	ND	ND	ND	ND	ND	ND	ND	0.007 (0.004 to 0.010)	ND
18	None	65	29 839	ND	ND	ND	ND	ND	ND	ND	0.003 (0.002 to 0.004)	ND
19	None	72	4101	ND	ND	ND	ND	ND	ND	ND	0.005 (0.002 to 0.008)	ND
20	None	74	8792	ND	ND	ND	ND	ND	ND	ND	0.014 (0.011 to 0.017)	ND
21	None	74	22 045	ND	ND	ND	ND	ND	ND	ND	0.012 (0.010 to 0.014)	ND
22	None	80	6249	ND	ND	ND	ND	ND	ND	ND	0.014 (0.010 to 0.018)	ND
23	None	82	10 341	ND	ND	ND	ND	ND	ND	ND	0.016 (0.014 to 0.018)	ND
24	None	84	11 821	ND	ND	ND	ND	ND	ND	ND	0.024 (0.020 to 0.028)	ND

Patients 1–13 had serial sections available and were used to score crypt bifurcation frequencies.
Patients 14–24 had only a single section available and were used to assess CCO− patch size.
AFAP, attenuated familial adenomatous polyposis; CCO, cytochrome c oxidase; FAP, familial adenomatous polyposis; ND, not detemined.