False-positive diagnosis of different fibrosis stages according to probe selection and steatosis grades
| Target | Cut-off | Probe | False-positive rate | |
| Grades 1–2 steatosis | Grade 3 steatosis | |||
| Entire population | ||||
| F2–F4 | ≥5.0 kPa | M | 39.7% (91/229) | 26.3% (30/114) |
| XL | 32.9% (78/237) | 27.9% (29/104) | ||
| ≥8.0 kPa | M | 20.8% (30/144) | 12.5% (10/80) | |
| XL | 10.2% (12/118) | 15.4% (8/52) | ||
| F3–F4 | ≥10.0 kPa | M | 31.4% (32/102) | 29.1% (16/55) |
| XL | 23.8% (20/84) | 19.2% (5/26) | ||
| >15.0 kPa | M | 17.1% (7/41) | 12.5% (2/16) | |
| XL | 15.4% (6/39) | 0% (0/11) | ||
| F4 | ≥10.0 kPa | M | 63.7% (65/102) | 74.5% (41/55) |
| XL | 53.6% (45/84) | 53.8% (14/26) | ||
| >15.0 kPa | M | 41.5% (17/41) | 50.0% (8/16) | |
| XL | 35.9% (14/39) | 27.3% (3/11) | ||
| BMI <30 kg/m2 | ||||
| F2–F4 | ≥5.0 kPa | M | 45.1% (60/133) | 25.5% (14/55) |
| XL | 40.3% (50/124) | 24.5% (12/49) | ||
| ≥8.0 kPa | M | 21.4% (15/70) | 8.6% (3/35) | |
| XL | 10.0% (5/50) | 4.5% (1/22) | ||
| F3–F4 | ≥10.0 kPa | M | 25.5% (12/47) | 19.2% (5/26) |
| XL | 14.7% (5/34) | 0% (0/11) | ||
| >15.0 kPa | M | 11.8% (2/17) | 0% (0/7) | |
| XL | 12.5% (2/16) | 0% (0/5) | ||
| F4 | ≥10.0 kPa | M | 59.6% (28/47) | 69.2% (18/26) |
| XL | 50.0% (17/34) | 54.5% (6/11) | ||
| >15.0 kPa | M | 29.4% (5/17) | 57.1% (4/7) | |
| XL | 25.0% (4/16) | 40.0% (2/5) | ||
| BMI ≥30 kg/m2 | ||||
| F2–F4 | ≥5.0 kPa | M | 32.3% (31/96) | 27.1% (16/59) |
| XL | 24.8% (28/113) | 30.9% (17/55) | ||
| ≥8.0 kPa | M | 20.3% (15/74) | 15.6% (7/45) | |
| XL | 10.3% (7/68) | 23.3% (7/30) | ||
| F3–F4 | ≥10.0 kPa | M | 36.4% (20/55) | 37.9% (11/29) |
| XL | 30.0% (15/50) | 33.3% (5/15) | ||
| >15.0 kPa | M | 20.8% (5/24) | 22.2% (2/9) | |
| XL | 17.4% (4/23) | 0% (0/6) | ||
| F4 | ≥10.0 kPa | M | 67.3% (37/55) | 79.3% (23/29) |
| XL | 56.0% (28/50) | 53.3% (8/15) | ||
| >15.0 kPa | M | 50.0% (12/24) | 44.4% (4/9) | |
| XL | 43.5% (10/23) | 16.7% (1/6) | ||
Results represent patients with 10 valid measurements and an IQR:median ratio of <0.30 by the corresponding probes. Numbers in brackets represent the numbers of patients with false-positive diagnosis divided by the total number of patients tested.
BMI, body mass index; LSM, liver stiffness measurement.