Clinical characteristics of OC subjects, PWS patients and PWS parents
| OC (n=17) | PWS (n=17) | PWS (n=24) | P value | |
| Female gender (%) | 59 | 59 | 63 | |
| T2D (%) | 18 | 24 | 0 | |
| BFMI | 19.8±6 | 18.2±7.2 | 0.487 | |
| Fat mass (%, DXA) | 47.2±7 | 47.6±6.7 | 0.8759 | |
| Age (year) | 31.4±8.9 | 29.4±7.8 | 59.1±7.3 | 0.4902 |
| Weight (kg) | 119.7±29.4 | 87.8±22.5 | 69.3±9.8 | 0.0013 |
| Height (cm) | 167.8±9 | 154.9±8.5 | 164.9±7.2 | <0.001 |
| BMI (kg/m2) | 42.3±8.7 | 37.4±10.1 | 25.5±3.7 | 0.1373 |
| Fat mass (kg) | 55.8±18 | 42.8±15.1 | 0.0299 | |
| Androgen fat (%) | 55.6±7.5** | 59.4±4.8 | 0.119 | |
| Fasting glycaemia (mmol/l) | 5.1±0.5 | 4.6±1 | 0.0914 | |
| Fasting insulin (mU/l) | 19.5±15.2** | 8.8±5** | 0.0236 | |
| HOMA-IR | 4.5±3.5** | 1.7±1** | 0.0133 | |
| HbA1c (%) | 5.6±0.6 | 5.7±0.5*** | 0.623 | |
| HDL-c (mmol/l) | 1.2±0.4 | 1.2±0.3 | 0.557 | |
| LDL-c (mmol/l) | 3.2±2.3 | 3±0.6 | 0.764 | |
| Triglycerides (mmol/l) | 1.7±1.8 | 1±0.4 | 0.1298 | |
| Leptin (ng/ml) | 51.5±29.1** | 38.6±24.3** | 0.2149 | |
| C-reactive protein (mg/l) | 6.8±3.9** | 12.4±12.5* | 0.1948 |
The values in Table indicates average value ±SD for continuous variables and percentage for factorial. P indicate significant differences in variable between OC and PWS using t-test, significant p values are in bold (alpha=0.05). Body fat mass index is calculated as body fat (kg) /height (m2). * n=10; ** n=14; *** n=16.
BFMI, body fat mass index; BMI, body mass index; DXA, dual-energy X-ray absorptiometry; HbA1c, haemoglobin A1c; HDL-c, high density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment of insulin resistance; LDL-c, low density lipoprotein cholesterol; OC, obese control; OWC, Over weigth control; PWS, Prader-Willi syndrome; T2D, type 2 diabetes.