Eosinophilic oesophagitis (EoO) in patients with and without IBD
| Crohn’s disease | UC | General population | |||||||
| EoO | No EoO | P values | EoO | No EoO | P values | EoO | No EoO | P values | |
| N | 2239 | 374 583 | 1267 | 327 108 | 102 048 | 133 206 291 | |||
| Incidence of EoO, per 105 person-years | 127.0 | N/A | 82.7 | N/A | 23.7 | N/A | |||
| Prevalence of EoO, per 105 persons | 594.2 | N/A | 385.8 | N/A | 76.6 | N/A | |||
| Age | <0.01 | <0.01 | <0.01 | ||||||
| Paediatric, n (%) | 424 (19.0) | 11 342 (3.0) | 125 (9.9) | 4644 (1.4) | 15 335 (15.0) | 24 607 944 (18.5) | |||
| Adult, n (%) | 1814 (81.0) | 363 057 (97.0) | 1140 (90.1) | 322 349 (98.6) | 86 681 (85.0) | 108 481 676 (81.5) | |||
| Overall, years (SD) | 33.4 (16.4) | 45.7 (15.1) | <0.01 | 41.3 (16.2) | 49.4 (13.8) | <0.01 | 38.7 (17.0) | 37.0 (18.6) | <0.01 |
| Sex, n (%) | <0.01 | <0.01 | |||||||
| Male | 1387 (62.0) | 163 707 (43.7) | 712 (56.3) | 146 639 (44.8) | 63 801 (62.5) | 65 144 344 (49.0) | |||
| Female | 851 (38.0) | 210 692 (56.3) | 553 (43.7) | 180 354 (55.2) | 38 215 (37.5) | 67 945 276 (51.0) | |||
| Region, n (%) | <0.01 | <0.01 | <0.01 | ||||||
| Northeast | 601 (26.8) | 94 888 (25.3) | 305 (24.1) | 79 412 (24.3) | 20 084 (19.7) | 23 064 663 (17.3) | |||
| Midwest | 492 (22.0) | 85 242 (22.8) | 301 (23.8) | 67 890 (20.8) | 25 747 (25.2) | 29 148 208 (21.9) | |||
| South | 724 (32.4) | 132 314 (35.3) | 399 (31.5) | 117 872 (36.0) | 35 112 (34.4) | 51 505 641 (38.7) | |||
| West | 388 (17.3) | 52 664 (14.1) | 246 (19.4) | 54 723 (16.7) | 18 899 (18.5) | 25 333 930 (19.0) | |||
| Unknown | 33 (1.5) | 9291 (2.5) | 14 (1.1) | 7096 (2.2) | 2174 (2.1) | 4 037 178 (3.0) | |||
| Immune-mediated comorbidities, n (%) | |||||||||
| Coeliac disease | 66 (3.0) | 3148 (0.8) | <0.01 | 21 (1.7) | 1632 (0.5) | <0.01 | 1240 (1.2) | 82 402 (0.1) | <0.01 |
| IBD-associated rheumatological conditions* | 349 (15.6) | 49 554 (13.2) | <0.01 | 184 (14.5) | 35 755 (10.9) | <0.01 | 8227 (8.1) | 4 064 945 (3.0) | <0.01 |
| Eczema | 67 (3.0) | 2653 (0.7) | <0.01 | 28 (2.2) | 2030 (0.6) | <0.01 | 2292 (2.2) | 587 054 (0.4) | <0.01 |
| Asthma | 495 (22.1) | 29 063 (7.8) | <0.01 | 241 (19.0) | 23 932 (7.3) | <0.01 | 18 366 (18.0) | 4 339 073 (3.2) | <0.01 |
*Includes inflammatory arthropathy, inflammatory spondyloarthropathy and psoriasis
N/A, not applicable.