HBV patient characteristics
| Variable | HC n=127 | F0 n=25 | F1 n=48 | F2 n=87 | F3 n=51 | F4 n=28 | P value |
| Age (years) | 39.3±10.6 | 38.5±7.5 | 40.0±11.2 | 40.8±11.4 | 43.5±11.8 | 42.3±10.9 | 0.2134 |
| Gender (F/M) | 78/49 | 13/12 | 17/31 | 36/51 | 14/37 | 7/21 | 0.0001 |
| ALT (U/L) | 12.8±9.26 | 49.0±67.3 | 73.4±124.2 | 135.8±207.5*** | 169.8±209.9***### | 181.0±339.4***### | 0.0001 |
| AST (U/L) | 20.1±6.8 | 39.8±33.2 | 64.4±100.6 | 95.4±169.5*### | 133.6±171.4**### | 164.0±278.8***### | 0.0001 |
| Cr (μmol/L) | 64.71±12.41*** | 66.64±15.44### | 70.48±13.54### | 69.75±14.50### | 79.74±25.58*### | 69.89±12.47### | 0.0001 |
| BUN (mmol/L) | 3.80±1.02* | 3.88±1.08# | 4.99±1.40### | 4.48±1.48### | 4.62±1.10### | 4.78±0.87### | 0.0001 |
| HBV DNA (log10IU/mL) | ND | 4.90±2.13 | 4.62±1.91 | 5.15±2.29 | 4.91±2.16 | 5.27±1.68 | 0.5185 |
| RBC (1012/L) | 4.71±0.53 | 4.54±0.62 | 4.83±0.61 | 5.03±3.37 | 4.78±0.52 | 4.53±0.54 | 0.1505 |
| WBC (109/L) | 6.17±1.67 | 5.25±1.33 | 5.82±1.51 | 5.69±1.57 | 5.40±1.49# | 5.01±1.61## | 0.0004 |
| PLT (109/L) | 233.8±51.50*** | 182.9±52.40### | 195.7±62.54### | 192.4±57.09### | 159.4±54.37### | 145.0±41.74**### | 0.0001 |
| HA (ng/mL） | ND | 31.92±30.19 | 79.79±110.3 | 117.3±169.7** | 158.0±214.7*** | 261.1±298.9*** | 0.0001 |
| PCIII (ng/mL） | ND | 11.85±8.87 | 8.11±5.53 | 9.45±15.23 | 10.79±7.93 | 14.16±8.20 | 0.0001 |
| LN (ng/mL） | ND | 74.49±37.11 | 53.14±51.78 | 49.99±42.32 | 67.22±61.70 | 79.90±58.53 | 0.0034 |
| CIV (ng/mL） | ND | 41.51±38.85 | 52.27±53.32 | 73.80±100.4 | 93.93±99.62** | 206.4±238.5*** | 0.0001 |
# P<0.05, ##p<0.01, ###p<0.001 compared with healthy controls. *p<0.05, **p<0.01, ***p<0.001 compared with F0 stage patients.
ALT, alanine transaminase; AST, aspartate transaminase; BUN, blood urea nitrogen; CⅣ, collagen Ⅳ; Cr, serum creatinine; HA, hyaluronic acid; LN, laminin; PCⅢ, procollagen type Ⅲ; RBC, red blood cell; WBC, white blood cell; PLT, platelet.