Risk factor | Univariate multivariate | Multivariate | ||
HR (95% CI) | P value | HR (95% CI) | P value | |
Sex | 1.1 (0.7 to 1.7) | 0.6 | 1.2 (0.7 to 2.2) | 0.5 |
Age at first diagnosis | 1.0 (1.0 to 1.1) | 0.04 | 1.0 (0.9 to 1.0) | 0.9 |
Presence of DS | 1.8 (1.2 to 2.8) | 0.008 | 2.7 (1.3 to 5.8) | 0.006 |
Presence of IBD | 1.4 (0.9 to 2.2) | 0.2 | 2.1 (1.0 to 4.3) | 0.03 |
PSC with features of AIH | 0.6 (0.3 to 1.3) | 0.2 | 0.1 (0.1 to 1.2) | 0.1 |
MRS | 1.5 (1.2 to 1.8) | <0.001 | 1.3 (1.1 to 1.7) | 0.02 |
Number of ERCP | 1.0 (0.9 to 1.0) | 0.8 | 0.4 (0.9 to 1.1) | 0.4 |
Non-adherence to scheduled ERCP | 1.7 (1.1 to 2.5) | 0.009 | 2.8 (1.4 to 5.6) | 0.005 |
Bold values indicate significant P -values (< 0.05).
AIH, autoimmune hepatitis; DS, dominant stricture; ERCP, endoscopic retrograde cholangiopancreatography; MRS, Mayo Risk Score; PSC, primary sclerosing cholangitis