Table 1

Summary of ‘credible positive associations’ from meta-analyses and credibility assessment

Gene	Variant	Cases vs controls (number of samples)	Allelic model					Power	Recessive model: var/var vs wt/wt and wt/var						Dominant model: wt/var and var/var vs wt/wt						Classification
			N	Effect size		Heterogeneity			N	Effect size		Heterogeneity		Power	N	Effect size		Heterogeneity		Power
			N	OR (95% CI)	P value	I² (95% CI)	P value		N	OR (95% CI)	P value	I² (95% CI)	P value	Power	N	OR (95% CI)	P value	I² (95% CI)	P value	Power
MUTYH	rs36053993	28 302 vs 20 935 (19*)	19	1.42 (1.22 to 1.66)	4.89E-06	0 (0 to 33)	0.703	0.99	na	na	na	na	na	na	19	1.31 (1.12 to 1.53)	0.001	0 (0 to 24)	0.837	0.88	Positive
MUTYH	rs34612342	28 180 vs 20 923 (19*)	17	1.89 (1.47 to 2.42)	5.72E-07	0 (0 to 62)	0.828	1.00	7	3.40 (1.22 to 9.48)	0.019	0 (0 to 0)	0.998	1.00	17	1.80 (1.39 to 2.31)	6.42E-06	0 (0 to 52)	0.884	1.00	Positive
SMAD7	rs12953717	28 006 vs 26 539 (13*)	13	1.11 (1.07 to 1.16)	6.24E-07	49 (0 to 93)	0.024	1.00	13	1.17 (1.08 to 1.26)	8.34E-05	45 (0 to 94)	0.041	1.00	13	1.14 (1.07 to 1.21)	5.00E-05	54 (10 to 95)	0.020	1.00	Positive
SMAD7	rs4464148	17 772 vs 17 356 (9*)	9	1.12 (1.08 to 1.16)	2.66E-09	12 (0 to 92)	0.337	1.00	9	1.13 (1.00 to 1.28)	0.054	49 (0 to 98)	0.047	0.97	9	1.16 (1.11 to 1.21)	2.09E-10	2 (0 to 86)	0.416	1.00	Positive
8q24	rs10505477	18 562 vs 20 132 (14)	14	1.14 (1.10 to 1.19)	2.04E-11	44 (0 to 82)	0.040	1.00	14	1.16 (1.10 to 1.23)	4.06E-07	35 (0 to 74)	0.092	1.00	14	1.24 (1.17 to 1.32)	1.04E-11	36 (0 to 81)	0.084	1.00	Positive
20p12.3	rs961253	22 971 vs 25 270 (14*)	14	1.11 (1.06 to 1.16)	1.58E-05	60 (28 to 91)	0.002	1.00	13	1.14 (1.06 to 1.22)	7.10E-04	36 (0 to 96)	0.098	1.00	14	1.14 (1.07 to 1.21)	4.75E-05	57 (21 to 88)	0.004	1.00	Positive
8q23.3	rs16892766	8351 vs 8878 (6*)	6	1.24 (1.15 to 1.34)	1.67E-08	4 (0 to 92)	0.393	0.99	6	1.21 (0.88 to 1.67)	0.240	0 (0 to 85)	0.747	0.22	6	1.27 (1.17 to 1.38)	4.00E-09	3 (0 to 90)	0.400	1.00	Positive
10p14	rs10795668	16 763 vs 18 302 (16*)	16	0.88 (0.83 to 0.94)	4.35E-05	67 (34 to 89)	6.94E-05	1.00	16	0.83 (0.77 to 0.89)	4.77E-07	11 (0 to 70)	0.332	1.00	16	0.85 (0.79 to 0.93)	2.27E-04	68 (34 to 87)	3.06E-05	1.00	Positive
11q23.1	rs3802842	22 320 vs 22 965 (20*)	20	1.15 (1.11 to 1.20)	5.21E-12	43 (0 to 78)	0.024	1.00	20	1.24 (1.13 to 1.35)	3.62E-06	45 (5 to 86)	0.017	1.00	20	1.19 (1.13 to 1.25)	7.22E-12	33 (0 to 70)	0.075	1.00	Positive
BMP2	rs355527	13 539 vs 14 375 (9)	9	1.12 (1.08 to 1.17)	1.65E-10	0 (0 to 0)	0.977	0.99	9	1.18 (1.09 to 1.27)	3.54E-05	0 (0 to 94)	0.458	0.99	9	1.16 (1.10 to 1.21)	2.43E-09	0 (0 to 9)	0.966	1.00	Positive
CDH1	rs1862748	17 436 vs 18 418 (11)	11	0.91 (0.88 to 0.94)	1.98E-08	0 (0 to 63)	0.703	0.98	11	0.83 (0.77 to 0.90)	1.59E-06	2 (0 to 68)	0.427	1.00	11	0.91 (0.87 to 0.95)	6.31E-06	0 (0 to 70)	0.511	0.99	Positive
RHPN2	rs7259371	15 762 vs 16 700 (9*)	9	0.87 (0.82 to 0.93)	1.65E-05	52 (0 to 90)	0.034	1.00	9	0.85 (0.73 to 0.98)	0.027	17 (0 to 86)	0.295	0.71	9	0.86 (0.80 to 0.92)	3.81E-06	42 (0 to 87)	0.084	1.00	Positive
TERT	rs2736100	16 176 vs 18 135 (8)	8	1.07 (1.04 to 1.10)	2.95E-05	0 (0 to 82)	0.526	0.88	8	1.06 (1.00 to 1.13)	0.069	15 (0 to 86)	0.316	0.64	8	1.13 (1.08 to 1.20)	2.03E-06	0 (0 to 64)	0.788	1.00	Positive
TGFB1	rs1800469	4021 vs 6024 (10)	10	0.89 (0.80 to 0.99)	0.036	53(2t o 92)	0.023	1.00	10	0.84 (0.74 to 0.94)	0.003	0 (0 to 75)	0.527	1.00	10	0.84 (0.71 to 1.00)	0.051	58 (15 to 92)	0.011	1.00	Positive

*Includes GWAS data from SOCCS.
GWASs, genome-wide association studies; SOCCS, Study of CRC in Scotland.