Most differentially expressed genes in the liver of 125 patients with severe obesity (Transcriptomic cohort) according to the presence of PNPLA3 I148M variant and of severe NAFLD
| Gene symbol | Description | Mean count | Log2(FC) ±SE | Adjusted p value |
| PNPLA3I148M carriersversusnon-carriers (n=65vs60) | ||||
| AC120194.1 | 72 | −2.31±0.44 | 0.003 | |
| NOVA1 | Neuro-oncological ventral antigen 1 | 14 | 0.91±0.19 | 0.006 |
| FAM13C | Family with sequence similarity 13, member C | 14 | 1.38±0.28 | 0.006 |
| TFF3 | Trefoil factor 3 (intestinal) | 171 | 1.77±0.37 | 0.009 |
| HDGF | Hepatoma-derived growth factor | 2305 | −0.25±0.05 | 0.009 |
| FCGR1A | Fc fragment of IgG high affinity Ia receptor | 10 | 1.29±0.28 | 0.010 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 82 | 0.55±0.12 | 0.013 |
| RALGDS | Ral guanine nucleotide dissociation stimulator | 122 | 0.59±0.13 | 0.014 |
| CDK5R1 | Cyclin-dependent kinase 5 regulatory subunit 1 (p35) | 15 | 0.82±0.18 | 0.016 |
| ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4 | 212 | 0.36±0.08 | 0.016 |
| Severe NAFLDversusnormal liver and simple steatosis (n=31vs94) | ||||
| IL32 | Interleukin-32 | 1530 | 1.36±0.21 | 1.2×10−6 |
| KRT8 | Keratin 8 | 3040 | 0.55±0.09 | 1.9×10−5 |
| PLP1 | Proteolipid protein 1 | 18 | −2.15±0.39 | 9.2×10−5 |
| DUSP8 | Dual specificity phosphatase 8 | 43 | 1.75±0.31 | 9.2×10−5 |
| SOCS1 | Suppressor of cytokine signalling 1 | 20 | 1.55±0.28 | 9.2×10−5 |
| COL1A1 | Collagen type I, alpha one chain | 518 | 0.79±0.16 | 0.001 |
| PRAMEF10 | PRAME family member 10 | 9 | 2.56±0.51 | 0.001 |
| UBD | Ubiquitin D | 135 | 1.27±0.25 | 0.001 |
| AKR1B10 | Aldo-keto reductase family 1, member B10 | 49 | 2.33±0.47 | 0.001 |
| FAM9B | Family with sequence similarity 9, member B | 17 | −1.58±0.33 | 0.002 |
| Severe NAFLDversusnot severe NAFLD –PNPLA3I148M non-carriers (n=12vs48) | ||||
| ACHE | Acetylcholinesterase (Yt blood group) | 16 | 2.32±0.49 | 0.014 |
| RGS18 | Regulator of G-protein signalling 18 | 24 | −2.19±0.47 | 0.014 |
| FAM43A | Family with sequence similarity 43, member A | 42 | −1.43±0.3 | 0.014 |
| C1QTNF5 | C1q and tumour necrosis factor related protein 5 | 102 | −1.54±0.33 | 0.014 |
| EXO5 | Exonuclease 5 | 48 | −1.38±0.31 | 0.023 |
| IL32 | Interleukin-32 | 1368 | 1.45±0.35 | 0.027 |
| ZNRD1 | Zinc ribbon domain containing 1 | 80 | −0.81±0.2 | 0.027 |
| COL1A1 | Collagen, type I, alpha 1 | 422 | 1.01±0.24 | 0.027 |
| C1orf162 | Chromosome one open reading frame 162 | 62 | 1.2±0.29 | 0.027 |
| GOLGA6A | Golgin A6 family, member A | 72 | −1.7±0.4 | 0.027 |
| Severe NAFLDversusnot severe NAFLD –PNPLA3I148M carriers (n=19vs46) | ||||
| KRT8 | Keratin 8 | 2854 | 0.65±0.11 | 9.7×10−5 |
| KRT18 | Keratin 18 | 1798 | 0.58±0.11 | 0.001 |
| AKR1B10 | Aldo-keto reductase family 1, member B10 | 65 | 3.02±0.6 | 0.003 |
| GPR132 | G protein-coupled receptor 132 | 15 | 1.55±0.32 | 0.006 |
| IL32 | Interleukin-32 | 1673 | 1.32±0.28 | 0.006 |
| CDH23 | Cadherin-related 23 | 306 | −1.08±0.23 | 0.006 |
| CYP17A1 | Cytochrome P450, family 17, subfamily A, polypeptide 1 | 47 | 1.93±0.42 | 0.006 |
| SOCS1 | Suppressor of cytokine signalling 1 | 23 | 1.86±0.4 | 0.006 |
| BIRC3 | Baculoviral IAP repeat containing 3 | 160 | 0.87±0.2 | 0.017 |
| CAPG | Capping protein (actin filament), gelsolin-like | 47 | 1.3±0.3 | 0.017 |
FC, fold change; NAFLD, non-alcoholic fatty liver disease; PNPLA3, patatin-like phospholipase domain-containing protein 3.