High adherence to a MedDiet attenuates the loss of diversity of the gut microbiome
| Low adherence | Medium adherence | High adherence | ||||||||||
| Estimate | Standard error | Z value | P value | Estimate | Standard error | Z value | P value | Estimate | Standard error | Z value | P value | |
| Intercept | 387.11 | 113.53 | 3.41 | 0.00065*** | 283.04 | 117.05 | 2.42 | 0.016* | 412.97 | 97.48 | 4.24 | 2.3e-5** |
| Time point | −9.51 | 4.85 | −1.96 | 0.049* | −9.34 | 4.99 | −1.87 | 0.061(.) | −3.84 | 4.93 | −0.78 | 0.44 |
| Gender | -2 | 12.34 | −0.16 | 0.87 | 16.97 | 12.62 | 1.34 | 0.179 | −7.40 | 10.93 | −0.68 | 0.5 |
| Age | −0.19 | 1.57 | −0.12 | 0.90 | 1.21 | 1.64 | 0.74 | 0.46 | −0.54 | 1.37 | −0.39 | 0.69 |
A significant decline in diversity was observed across the time points in the low adherence group (as indicated in the estimate value).
Data tabulated are from regression analysis of the change in gut microbial diversity across the time points (baseline vs final), taking age and gender as the confounders in the three adherence change groups.
The decline attenuated from being marginally significant in the medium adherence group to non-significant in the high adherence group. Please refer to the Methods section for the definition of ‘low’, ‘medium’ and ‘high’ adherence groups of individuals.
The notations used for the p-values of significance are **P < 0.01; *P < 0.05 and; ***P < 0.10