Table 1

Urinary urolithins-glucuronides levels (ng/µmol creatinine) detected over the study period

MedDConDP values
Baseline48wBaseline4w8wΔ(4w – baseline)Δ(8w – baseline)
Urolithin-A-glucuronide30.8±37.7139.8±296.8214.4±3585.4±30.56.9±35.75±28.30.0130.025
Urolithin-B-glucuronide0.1±0.721.7±60.674.1±243.40.2±0.90.1±0.55.4±30.60.00730.086
Urolithin-C-glucuronide1.6±8.846.8±107.243.2±176.60±00±00±00.0210.16
Total urolithins (A+B+C)32.6±91.8208.3±373.8336.7±594.35.5±30.57±35.710.4±410.000340.033
  • Data are expressed as mean±SD. P values refer to variation at the specific time point compared with baseline in MedD versus ConD measured by unpaired Wilcoxon rank-sum test.

  • 4w, 4 weeks; 8w, 8 weeks.