Table 1

Proportion of Phb1ⁱ^Δ^IEC mice that manifest mitochondrial dysfunction, abnormal Paneth and goblet cells, and histological inflammation

Week after Phb1 deletion	Mice with mitochondrial dysfunction* N (%)	% mice with abnormal Paneth cells† n (%)	% mice with abnormal AB⁺ cells‡n (%)	% mice with histological inflammation n (%)
1	12/12 (100)	4/12 (25)	0/12 (0)	0/12 (0)
3	12/12 (100)	7/12 (58)	2/12 (12)	2/12 (17)
6	N/D	10/14 (78)	6/14 (43)	6/14 (43)
12	15/15 (100)	13/15 (87)	13/15 (87)	13/15 (87)

*Defined as increased mtUPR, ultrastructural abnormalities in IECs by TEM.
†Defined as altered lysozyme staining, less abundant secretory granules, and AB⁺ staining.
‡Defined as enlarged, more abundant AB⁺ cells above the crypt base.
IEC, intestinal epithelial cell; mtPUR, mitochondrial unfolded protein response; N/D, not determined; Phb1ⁱ^Δ^IEC, intestinal epithelial cell deletion of Phb1; TEM, transmission electron microscopy.