Table 2

Risk of developing dementia among patients with IBD and controls*

Alzheimer’s diseaseVascular dementiaUnspecified dementiaTotal
Stratified Cox-regression model (HR (95% CI))
IBD (presence vs absence)6.19 (3.31 to 11.57)2.60 (1.18 to 5.70)2.88 (2.11 to 3.93)2.54 (1.91 to 3.37)
Stratified by disease
 UC6.77 (2.82 to 16.22)4.39 (1.64 to 11.80)3.10 (2.12 to 4.51)2.69 (1.89 to 3.85)
 CD7.53 (2.67 to 21.28)1.10 (0.24 to 5.15)2.46 (1.42 to 4.28)2.29 (1.42 to 3.69)
Stratified by sex
 Male IBD4.87 (1.80 to 13.16)6.67 (2.44 to 18.25)3.10 (2.02 to 4.77)2.79 (1.87 to 4.18)
 Female IBD7.67 (3.36 to 17.49)0.57 (0.15 to 2.25)2.80 (1.79 to 4.40)2.43 (1.63 to 3.64)
Stratified competing risk regression model (HR (95% CI))
IBD (presence vs absence)7.06 (3.88 to 12.83)1.93 (0.90 to 4.14)2.25 (1.56 to 3.24)2.55 (1.92 to 3.39)
Stratified by disease
 UC7.95 (3.56 to 17.75)2.47 (0.96 to 6.43)2.39 (1.52 to 3.76)2.69 (1.88 to 3.85)
 CD7.86 (2.81 to 21.99)1.09 (0.25 to 4.75)2.01 (1.07 to 3.76)2.32 (1.43 to 3.75)
Stratified by sex
 Male IBD5.34 (2.10 to 13.57)4.67 (1.78 to 12.24)2.39 (1.41 to 4.07)2.88 (1.91 to 4.32)
 Female IBD8.75 (3.96 to 19.35)0.72 (0.16 to 3.18)2.21 (1.32 to 3.68)2.41 (1.61 to 3.60)
  • Bold type indicates the statistical significance.

  • *Adjusted by age, Charlson Comorbidity Index score and all-cause clinical visits.

  • CD, Crohn’s disease; CI, confidence interval; HR, hazard ratio; IBD, inflammatory bowel disease; UC, ulcerative colitis.