Table 1

Demographic data and incidence of dementia among patients with IBD and control group

Patients with IBD
(n=1742)
Controls
(n=17 420)
Patients with CD
(n=584)
Controls
(n=5840)
Patients with UC
(n=1158)
Controls
(n=11 580)
Age at enrolment (years, SD)60.64 (10.75)60.63 (10.76)61.41 (11.04)61.40 (11.05)60.26 (10.58)60.24 (10.59)
Sex (n, %)
 Male894 (51.3)8940 (51.3)301 (51.5)3010 (51.5)593 (51.2)5930 (51.2)
 Female848 (48.7)8480 (48.7)283 (48.5)2830 (48.5)565 (48.8)5650 (48.8)
IBD diagnosis (n, %)
 CD584 (33.5)
 UC1158 (66.5)
Disease severity (n, %)
 Mild1323 (75.9)482 (82.5)841 (72.6)
 Moderate–severe288 (16.5)64 (11.0)224 (19.3)
 Surgery131 (7.5)38 (6.5)93 (8.0)
Dementia-related comorbidities (n, %)
 Cerebrovascular diseases310 (17.8)3100 (17.8)110 (18.8)1100 (18.8)200 (17.3)2000 (17.3)
 Traumatic brain injury46 (2.6)460 (2.6)12 (2.1)120 (2.1)34 (2.9)340 (2.9)
 Hypertension919 (52.8)9190 (52.8)319 (54.6)3190 (54.6)600 (51.8)6000 (51.8)
 Dyslipidaemia562 (32.3)5620 (32.3)209 (35.8)2090 (35.8)353 (30.5)3530 (30.5)
 Diabetes mellitus425 (24.4)4250 (24.4)150 (25.7)1500 (25.7)275 (23.7)2750 (23.7)
 Smoking31 (1.8)310 (1.8)5 (0.9)50 (0.9)26 (2.2)260 (2.2)
CCI score (SD)3.48 (2.55)2.59 (2.35)3.60 (2.48)2.64 (2.35)3.42 (2.58)2.56 (2.35)
Level of urbanisation (n, %)
 1 (most urbanised)207 (11.9)2070 (11.9)76 (13.0)760 (13.0)131 (11.3)1310 (11.3)
 2337 (19.3)3370 (19.3)93 (15.9)930 (15.9)244 (21.1)2440 (21.1)
 3189 (10.8)1890 (10.8)69 (11.8)690 (11.8)120 (10.4)1200 (10.4)
 4149 (8.6)1490 (8.6)39 (6.7)390 (6.7)110 (9.5)1100 (9.5)
 5 (most rural)860 (49.4)8600 (49.4)307 (52.6)3070 (52.6)553 (47.8)5530 (47.8)
Income-related insured amount
 ≤15 840 NTD/month741 (42.5)7410 (42.5)252 (43.2)2520 (43.2)489 (42.2)4890 (42.2)
 15 841–25 000 NTD/month636 (36.5)6360 (36.5)209 (35.8)2090 (35.8)427 (36.9)4270 (36.9)
 ≥25 001 NTD/month365 (21.0)3650 (21.0)123 (21.0)1230 (21.0)242 (20.9)2420 (20.9)
Incidence of any dementia (n, %)95 (5.5)250 (1.4)30 (5.1)93 (1.6)65 (5.6)157 (1.4)
 Age at diagnosis of any dementia (years, SD)76.24 (8.22)83.45 (6.32)75.94 (7.84)83.07 (7.11)76.37 (8.45)83.69 (58.2)
 Duration between enrolment and dementia (years, SD)5.93 (3.57)7.32 (4.45)5.49 (3.16)6.34 (4.41)6.13 (3.75)7.90 (4.39)
 Dementia type (n, %)
  Alzheimer’s disease33 (1.9)32 (0.2)11 (1.9)14 (0.2)22 (1.9)18 (0.2)
  Vascular dementia12 (0.7)40 (0.2)3 (0.5)16 (0.3)9 (0.8)24 (0.2)
  Unspecified50 (2.9)178 (1.9)16 (2.8)63 (1.1)34 (2.9)115 (1.0)
All-cause clinical visits (times per year, SD)25.17 (25.59)15.01 (15.04)24.45 (21.38)15.65 (16.15)25.54 (27.47)14.68 (14.44)
All-cause mortality (n, %)22 (1.3)126 (0.7)7 (1.2)37 (0.6)15 (1.3)89 (0.8)
  • CCI, Charlson Comorbidity Index; CD, Crohn’s disease; IBD, inflammatory bowel disease; SD, standard deviation; UC, ulcerative colitis.