Table 4

Studies of PPI and amoxicillin dual therapies as first-line Helicobacter pylori treatment

StudiesStudy designSample sizeDose of PPIDose of amoxicillinTreatment duration (days)Eradication rates (ITT)
Koizumi W et al 32 RCT31Omeprazole 20 mg qd500 mg tid1442%
Cottrill MR et al 33 RCT85Omeprazole 40 mg qd1000 mg twice daily1444%
Wong BC et al 34 RCT75Lansoprazole 30 mg twice daily1000 mg twice daily1457%
Schwartz H et al 35 RCT60Lansoprazole 30 mg twice daily1000 mg tid1445%
Schwartz H et al 35 RCT60Lansoprazole 30 mg tid1000 mg tid1470%
Yang J et al 36 RCT116Esomeprazole 20 mg qid750 mg qid1488%
Yu L et al 37 RCT80Esomeprazole 40 mg twice daily1000 mg tid1493%
Yang JC et al 38 RCT150Rabeprazole 20 mg qid750 mg qid1495%
Furuta et al 39 Retrospective study56Vonoprazan 20 mg twice daily500 mg tid793%
Present studyRCT168Vonoprazan 20 mg twice daily750 mg twice daily785%
  • ITT, intention-to-treat; PPI, proton-pump inhibitor; qd, once daily; qid, four times daily; RCT, randomised controlled trial; tid, three times daily.