Incidence rates* and HRs of PD for the total sample and subgroups
Types of Analysis | Not exposed to GIIs | Exposed to GIIs | Cox regression (ref.: not exposed to GIIs) | |||||||
Events | Person years | IR | Events | Person years | IR | Cr. HR | 95% CI | Adj. HR | 95% CI | |
Overall† | 5020 | 1 704 049 | 2.95 | 1175 | 250 573 | 4.69 | 1.42 | 1.33 to 1.52 | 1.42 | 1.33 to 1.52 |
Men‡ | 2327 | 724 388 | 3.21 | 493 | 93 896 | 5.25 | 1.48 | 1.34 to 1.63 | 1.48 | 1.34 to 1.63 |
Women‡ | 2693 | 979 661 | 2.75 | 682 | 156 677 | 4.35 | 1.38 | 1.27 to 1.50 | 1.38 | 1.27 to 1.50 |
Age <70 years§ | 1062 | 862 501 | 1.23 | 162 | 114 127 | 1.42 | 1.17 | 0.99 to 1.38 | 1.17 | 0.99 to 1.38 |
Age ≥70 years§ | 3958 | 841 548 | 4.70 | 1013 | 136 446 | 7.42 | 1.25 | 1.04 to 1.49 | 1.25 | 1.04 to 1.49 |
Without COPD¶ | 4051 | 1 438 104 | 2.82 | 858 | 191 598 | 4.48 | 1.65 | 1.53 to 1.78 | 1.43 | 1.33 to 1.54 |
With COPD¶ | 969 | 265 945 | 3.64 | 317 | 58 975 | 5.38 | 1.51 | 1.33 to 1.72 | 1.40 | 1.23 to 1.59 |
Without SRC¶ | 4650 | 1 613 378 | 2.88 | 1065 | 230 044 | 4.63 | 1.66 | 1.55 to 1.78 | 1.40 | 1.35 to 1.55 |
With SRC¶ | 370 | 90 671 | 4.08 | 110 | 20 529 | 5.36 | 1.93 | 1.59 to 2.33 | 1.20 | 0.96 to 1.48 |
N=228 485; PD cases=6195.
*Per 1000 person years.
†HRs were adjusted for gender, age, diabetes mellitus, cerebrovascular diseases, hypertension, ischaemic heart diseases, hypercholesterolaemia, chronic obstructive pulmonary disease and intracranial injury.
‡HRs were adjusted for age, diabetes mellitus, cerebrovascular diseases, hypertension, ischaemic heart diseases, hypercholesterolaemia, chronic obstructive pulmonary disease and intracranial injury.
§HRs were adjusted for gender, diabetes mellitus, cerebrovascular diseases, hypertension, ischaemic heart diseases, hypercholesterolaemia, chronic obstructive pulmonary disease and intracranial injury.
¶HRs were adjusted for gender, age, diabetes mellitus, cerebrovascular diseases, hypertension, ischaemic heart diseases, hypercholesterolaemia and intracranial injury,
Adj. HR, adjusted HR; COPD, chronic obstructive pulmonary disease; Cr. HR, crude HR; GII, GI infections; IR, incidence rate; PD, Parkinson’s disease; SRC, smoking-related cancers.