Cohort characteristics for the seven cohorts of samples included in this study
| Cohort | Origin | Type | Preparation | Sample size | Pathology | Mean age | M:F ratio | |
| Discovery | Polyps | Internal (S:CORT) | Biopsy | Fresh/frozen | n=54 | Adenoma | 67.0 | 1.00 |
| A (DC-A) | TCGA9 | Resection | Fresh/frozen | n=618 | Carcinoma (colon, rectum) | 66.4 | 1.15 | |
| B (DC-B) | Genentech11 | Resection | Fresh/frozen | n=66 | Carcinoma (colon) | NA | NA | |
| Pancancer | TCGA17 | Resection | Fresh/frozen | n=10 542 | Carcinoma (non-colorectal) | 59.1 | 0.92 | |
| Validation | A (Val-A) | Internal (S:CORT) | Resection | FFPE | n=348 | Carcinoma (colon, rectum) | 63.5 | 1.79 |
| B (Val-B) | Internal (S:CORT) | Biopsy | FFPE | n=230 | Carcinoma (rectum) | 67 | 1.71 | |
| Clinical application | Internal | Resection | FFPE | n=63 | Carcinoma (rectum) | 70.4 | 1.63 | |
FFPE, formalin-fixed paraffin embedded; NA, not available; S:CORT, Stratification in Colorectal Cancer.