Table 4

Results of oesophageal function tests, endoscopy and questionnaires in treated achalasia patients with (RS+) and without reflux symptoms (RS–)

Patients with reflux symptoms (RS+)Patients without reflux symptoms (RS–-)P value
(n=19)(n=19)
High-resolution manometry
 Basal LOS pressure (mm Hg, median (IQR))3 (2–6)3 (3–6)0.88
 Integrated relaxation pressure (mm Hg, median (IQR))6.2 (2.1–8.7)5.9 (4.1–9)0.87
Classification of oesophageal contractility1
 Failed contractility (n (%))13 (68)13 (68)
 Weak contractility (n (%))6 (32)6 (32)
OGJ distensibility (at 50 mL: mm2/mm Hg, median (IQR))5.3 (4.5–6.9)5.3 (4.5–6.9)0.18
Timed barium oesophagogram
 Barium column at 5 min (cm, median (IQR))1 (0–2)1.8 (0–2.5)0.34
 Barium column at 2 min1.6 (0–2)2.4 (1–3.5)0.1
 Oesophageal diameter (cm, median (IQR))2.1 (1.8–3)2.5 (2–3.4)0.12
Endoscopy
Reflux oesophagitis (n (%))10 (53)4 (21)0.91
 Grade A5/10 (50)2/4 (50)
 Grade B5/10 (50)2/4 (50)
Questionnaires (median (IQR))
RDQ total score*1.9 (1.4–3.3)0.3 (0–0.6)<0.001
 Heartburn3 (2–4.3)0 (0–1)<0.001
 Regurgitation1 (0.8–2.8)0 (0–0.3)<0.001
 Dyspepsia1.8 (0–4)0 (0–0.5)<0.002
 GORD2.1 (1.5–2.8)0.3 (0–0.8)<0.001
Achalasia-DSQoL†19 (14–22)13 (12–16)<0.005
SF-36‡
 Physical component summary score51 (46–55)54 (51–58)0.06
 Mental component summary score57 (53–60)54 (53–58)0.37
  • *RDQ: 12-item questionnaire, providing a score for each typical reflux symptom on a Likert scale, range 0 to5. Per domain the mean score was calculated per patient.

  • †Achalasia-DSQoL: quality of life related to achalasia, range 10 to 33, lower score indicated better quality of life.

  • ‡SF-36 score consisted of a physical and mental component summary score, each ranged from 0 to 100, with higher scores indicating better quality of life.

  • DSQoL, Disease-Specific Quality-of-Life questionnaire; GORD, gastro-oesophageal reflux dimension; LOS, lower oesophageal sphincter; OGJ, oesophagogastric junction; RDQ, Reflux Disease Questionnaire; SF-36, 36-item Short-Form Health Survey.