Table 1

Clinical characteristics of OC subjects, PWS patients and PWS parents

PWS (n=24)P value
Female gender (%)595963
T2D (%)18240
Fat mass (%, DXA)47.2±747.6±6.70.8759
Age (year)31.4±8.929.4±7.859.1±7.30.4902
Weight (kg)119.7±29.487.8±22.569.3±9.8 0.0013
Height (cm)167.8±9154.9±8.5164.9±7.2 <0.001
BMI (kg/m2)42.3±8.737.4±10.125.5±3.70.1373
Fat mass (kg)55.8±1842.8±15.1 0.0299
Androgen fat (%)55.6±7.5**59.4±4.80.119
Fasting glycaemia (mmol/l)5.1±0.54.6±10.0914
Fasting insulin (mU/l)19.5±15.2**8.8±5** 0.0236
HOMA-IR4.5±3.5**1.7±1** 0.0133
HbA1c (%)5.6±0.65.7±0.5***0.623
HDL-c (mmol/l)1.2±0.41.2±0.30.557
LDL-c (mmol/l)3.2±2.33±0.60.764
Triglycerides (mmol/l)1.7±1.81±0.40.1298
Leptin (ng/ml)51.5±29.1**38.6±24.3**0.2149
C-reactive protein (mg/l)6.8±3.9**12.4±12.5*0.1948
  • The values in Table indicates average value ±SD for continuous variables and percentage for factorial. P indicate significant differences in variable between OC and PWS using t-test, significant p values are in bold (alpha=0.05). Body fat mass index is calculated as body fat (kg) /height (m2). * n=10; ** n=14; *** n=16.

  • BFMI, body fat mass index; BMI, body mass index; DXA, dual-energy X-ray absorptiometry; HbA1c, haemoglobin A1c; HDL-c, high density lipoprotein cholesterol; HOMA-IR, homeostatic model assessment of insulin resistance; LDL-c, low density lipoprotein cholesterol; OC, obese control; OWC, Over weigth control; PWS, Prader-Willi syndrome; T2D, type 2 diabetes.