Table 1

Urinary urolithins-glucuronides levels (ng/µmol creatinine) detected over the study period

	MedD			ConD			P values
	Baseline	4	8w	Baseline	4w	8w	Δ_{(4w – baseline)}	Δ_{(8w – baseline)}
Urolithin-A-glucuronide	30.8±37.7	139.8±296.8	214.4±358	5.4±30.5	6.9±35.7	5±28.3	0.013	0.025
Urolithin-B-glucuronide	0.1±0.7	21.7±60.6	74.1±243.4	0.2±0.9	0.1±0.5	5.4±30.6	0.0073	0.086
Urolithin-C-glucuronide	1.6±8.8	46.8±107.2	43.2±176.6	0±0	0±0	0±0	0.021	0.16
Total urolithins (A+B+C)	32.6±91.8	208.3±373.8	336.7±594.3	5.5±30.5	7±35.7	10.4±41	0.00034	0.033

Data are expressed as mean±SD. P values refer to variation at the specific time point compared with baseline in MedD versus ConD measured by unpaired Wilcoxon rank-sum test.
4w, 4 weeks; 8w, 8 weeks.