Subject characteristics and sample sizes for the Irish and the Canadian cohorts
| Type of cohort | Manitoba | Cork | ||||||||
| CD | UC | Non-IBD control | CD | UC | Non-IBD control | |||||
| Number of subjects | 186 | 144 | 79 | 117 | 84 | 82 | ||||
| Gender (%female) | 72.0 | 58.3 | 36.7 | 48.7 | 36.9 | 50.0 | ||||
| Age (mean±SD) | 54.4±12.6 | 56.9±12.6 | 57.6±15.9 | 41.0±11.7 | 45.6±12.6 | 40.88±16.5 | ||||
| Age of disease onset (mean±SD) | 30.5±11.9 | 36.1±13.2 | NA | 26.4±10.6 | 30.8±12.1 | NA | ||||
| Sample type (all time points) | Active | Inactive | Active | Inactive | Non-IBD control | Active | Inactive | Active | Inactive | Non-IBD control |
| Number of samples | 238 | 340 | 167 | 324 | 96 | 55 | 180 | 61 | 150 | 179 |
| Prior resection (%) | 47.5 | 41.8 | 91.6 | 91.7 | NA | 65.5 | 52.2 | 93.4 | 98.0 | NA |
| Smoking status | ||||||||||
| Non (%) | 40.1 | 41.1 | 35.4 | 39.8 | 51.9 | 55.3 | ||||
| Ex (%) | 44.3 | 44.2 | 24.0 | 48.1 | 41.5 | 14.5 | ||||
| Current (%) | 9.5 | 6.1 | 2.1 | 12.0 | 6.6 | 6.1 | ||||
| Alcohol consumption | ||||||||||
| >2 units per day (%) | 3.3 | 4.9 | 11.5 | 12.0 | 9.9 | 5.0 | ||||
| <2 units per day (%) | 47.9 | 49.1 | 38.5 | 42.3 | 47.2 | 31.8 | ||||
| Non (%) | 42.9 | 37.5 | 11.5 | 45.6 | 41.5 | 14.0 | ||||
| Medication | ||||||||||
| Biologics (%) | 17.6 | 8.0 | 4.2 | 2.8 | 0.0 | 27.3 | 20.6 | 11.5 | 10.7 | 0.0 |
| 5-ASA (%) | 26.9 | 25.0 | 50.9 | 49.4 | 0.0 | 40.0 | 32.8 | 57.4 | 57.3 | 0.0 |
| Mercaptopurine (%) | 13.9 | 24.1 | 11.4 | 11.4 | 0.0 | 14.5 | 22.2 | 18.0 | 24.7 | 0.0 |
| Corticosteroids (%) | 5.9 | 3.5 | 9.6 | 3.7 | 1.0 | 25.5 | 10.6 | 24.6 | 7.3 | 1.1 |
| Proton pump inhibitors (%) | 26.1 | 20.9 | 23.4 | 11.1 | 31.3 | 18.2 | 18.3 | 4.9 | 17.3 | 2.2 |
| Other gastrointestinal drugs (%) | 19.3 | 22.1 | 13.8 | 7.1 | 2.1 | 14.5 | 10.0 | 3.3 | 6.7 | 1.1 |
| Antibiotics (%) | 2.9 | 4.4 | 4.2 | 0.9 | 0.0 | 0.0 | 0.0 | 1.6 | 0.7 | 0.0 |
| Supplements (%) | 60.9 | 66.8 | 47.9 | 45.4 | 21.9 | 12.7 | 20.6 | 14.8 | 18.0 | 10.1 |
| NSAIDs (%) | 28.2 | 28.5 | 31.1 | 23.1 | 18.8 | 14.5 | 4.4 | 0.0 | 8.0 | 1.7 |
| Diabetes drugs (%) | 1.7 | 1.7 | 6.6 | 4.9 | 0.0 | 3.6 | 3.9 | 4.9 | 4.0 | 0.0 |
5-ASA, 5-aminosalicylic acid; NSAIDs, non-steroidal anti-inflammatory drugs.