Table 3

Regression analysis of factors influencing thiopurine effectiveness in CD and UC patients

CDUC
UnivariableMultivariableUnivariableMultivariable
OR (95% CI)P valueOR (95% CI)P valueOR (95% CI)P valueORP value
Age at diagnosis1.02 (1.01 to 1.02)<0.00011.01 (1.01 to 1.02)<0.00011 (1.00 to 1.01)0.49  
Gender 0.08   0.72  
 Male1.09 (0.99 to 1.20)   1.02 (0.91 to 1.14)   
 FemaleReferent   Referent   
Smoking history 0.34   0.12  
 No0.95 (0.86 to 1.05)   1.01 (0.98 to 1.23)   
 YesReferent   Referent   
Treatment era  1.2 (1.14 to 1.25)<0.0001  0.88 (0.83 to 0.93)<0.0001
Time from diagnosis to thiopurine initiation        
 <1 year0.72 (0.64 to 0.82)<0.00010.69 (0.60 to 0.78)<0.00010.87 (0.76 to 1.0)0.36  
 ≥1 and <2 years0.92 (0.80 to 1.06)0.240.81 (0.70 to 0.95)0.810.86 (0.74 to 1.0)0.27  
 ≥2 yearsReferent       
Disease location (CD)        
 Ileal1.28 (1.14 to 1.45)0.57      
 Colonic1.61 (1.42 to 1.84)0.0081.6 (1.38 to 1.86)0.002    
 Exclusive upper GI1.53 (0.96 to 2.46)0.44      
 Ileo-colonicReferent       
Perianal involvement        
 Yes0.67 (0.59 to 0.75)<0.00010.7 (0.61 to 0.80)<0.0001    
 NoReferent       
Disease location (UC)        
 Proctitis (E1)    1.47 (1.17 to 1.84)0.00061.56 (1.23 to 1.98)0.0002
 Left sided (E2)    1.01 (0.89 to 1.14)0.01  
 Extensive (E3)    Referent   

  • Significant p values shown in bold.

  • CD, Crohn’s disease; UC, ulcerative colitis.