Table 2

Characteristics of randomised controlled trials of H. pylori eradication therapy versus placebo or no treatment in the prevention of future gastric cancer in individuals with gastric neoplasia undergoing endoscopic mucosal resection

StudyLocationMethod used to confirm presence of H. pylori Sample size (no. receiving H. pylori eradication therapy)Characteristics of participants H. pylori eradication therapy regimen usedEradication rate*Last point of follow-upMethod of ascertainment of gastric cancer cases
Fukase 2008 32 Fifty-one hospitals in JapanHistological examination of, and rapid urease testing using, gastric biopsies obtained at upper gastrointestinal endoscopy.544 (272)Median age 68.5 years (range 20–79 years), 76.4% male.Lansoprazole 30 mg, amoxicillin 750 mg and clarithromycin 200 mg b.i.d. for 1 week.74.9%3 years.Histological examination of gastric biopsies obtained at upper gastrointestinal endoscopy at ≥3 years.
Choi 2018a 33 One hospital in Seoul, South Korea.Histological examination of, and rapid urease testing using, gastric biopsies obtained at upper gastrointestinal endoscopy.901 (444)Mean age 60.4 years (range 20–75 years), 67.7% male.Omeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg b.i.d. for 1 week.81.3%6 years.Histological examination of gastric biopsies obtained at upper gastrointestinal endoscopy.
Choi 2018b 34 One hospital in Goyang, South Korea.Histological examination of, and rapid urease testing using, gastric biopsies obtained at upper gastrointestinal endoscopy.396 (194)Mean age 59.8 years (range 18–75 years), 75.3% male.Rabeprazole 10 mg, amoxicillin 1 g, and clarithromycin 500 mg b.i.d. for 1 week.80.4%5.9 years.Histological examination of gastric biopsies obtained at upper gastrointestinal endoscopy at 3 months and 3 years.
  • *True intention-to-treat analysis, with all drop-outs assumed to have failed eradication therapy.

  • b.i.d., two times per day; H. pylori, Helicobacter pylori.